摘要
目的：建立犬慢性快速心房起搏房颤模型，为进一步探讨房颤发生的机制做好实验用准备。方法：选取健康成年家犬10只（1-2岁），雌雄不限，体重（18±0．5）b。建立慢性快速心房起搏房颤模型成功。结果：慢性快速心房起搏模型的建立制作简单，容易诱发心房肌电重构，导致房颤发生和维持。适用于实验及后续性药物研究的需要。结论：犬慢性快速心房起搏房颤模型具有房颤诱发率高、持续时间长、重复性好等特点。
Objective To establish a canine model of chronic rapid atrial pacing in atrial fibrillation, in order to further explore the mechanisms for the experimental preparation. Method Total 10 healthy adult dogs （1 ~ 2 years old） ,irrespective of gender,weight 18 ± 0. 5kg. Chronic rapid atrial pacing to establish a successful model of atrial fibrillation. Results Chronic rapid atrial pacing model of producing simple, easily induced atrial electrical remodeling,leading to atrial fibrillation and maintenance. And follow -up for experimental drug research needs. Conclusion Canine model of chronic atrial fibrillation with rapid atrial pacing induced high atrial fibrillation rate,long duration, repetition is good.
出处
《吉林医学》
CAS
2011年第4期640-642,共3页
Jilin Medical Journal
