摘要
目的:评价益生菌联用质子泵抑制剂治疗由幽门螺杆菌感染所致消化性溃疡的疗效。方法:选择临床确诊的由幽门螺杆菌感染所致的消化性溃疡患者96例,分A、B组。A组50例,给予双歧四联活菌剂+奥美拉唑;B组46例,给予克拉霉素+甲硝唑+奥美拉唑。结果:A组幽门螺杆菌根除的有效率和根除率分别为84.0%,88.0%,B组分别为91.3%,89.1%,2组比较差异无显著性(P>0.05);不良反应发生率:A组为4.0%,B组为32.6%,2组有显著差异(P<0.05)。结论:益生菌联合质子泵抑制剂治疗Hp感染安全、有效,值得推广。
OBJECTIVE To evaluate the curative effect of probiotics combined with PPI to treat peptic ulcer caused by Helicobacter pylori （Hp）. METHODS 96 clinical cases were selected with a definite diagnosis of peptic ulcer caused by Hp, and di- vided into group A and B. Group A, with 50 cases, was given combined Bifidobacteriura, Lactobacillus, Enterococcus and Bacillus cereus tables and omeprazole （OME） ; while group B,with 46 cases,was given CLA, metronidazole （MTZ） and OME. RESULTS The effective rate and eradication rate of Hp affection for group A was 84. 0% and 88. 0% respectively; the effective rate and eradication rate for group B was 91.3% and 89. 1% respectively. There was no significant difference between two groups （P〉0. 05） ; while the occurrence rate of adverse reaction was 4. 0% for Group A and 32. 6% for Group B, and two groups have significant differences （P〈0. 05）. CONCLUSION The treatment of HP affection using probiotics combined with PPI was safe and effective,which can be widely used in clinic.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第4期315-316,共2页
Chinese Journal of Hospital Pharmacy
关键词
益生菌制剂
质子泵抑制剂
幽门螺杆菌
probiotic preparation
proton pump inhibitors
Helicobacter pylori
