摘要
目的:研究玉泉丸对盐酸二甲双胍大鼠肠吸收的影响。方法:采用大鼠在体肠单向灌流吸收实验模型,应用重量法校正灌流液体积,考察玉泉丸对盐酸二甲双胍肠吸收的影响。结果:盐酸二甲双胍组、盐酸二甲双胍与玉泉丸联合灌流组、玉泉丸诱导组的吸收速率常数分别为0.38,0.28,0.38min-1,吸收渗透系数分别为0.38,0.29,0.37cm.min-1。结论:玉泉丸可能竞争盐酸二甲双胍大鼠肠吸收途径,对盐酸二甲双胍的吸收有一定的抑制作用。
OBJECTIVE To evaluate the effect of Yuquan Pill on absorption of metformin by small intestine in rat. METHODS The rat single-pass intestinal perfusion technique was applied, and the gravimetry was used to correct the perfusion volume. The effect of Yuquan Pill on absorption of metfomlin was studied. RESULTS The absorption rate constant at the metformin group, metformin combined with Yuquan Pill group and Yuquan Pill induced group were 0. 38,0. 28,0. 38 min^-1 and the apparent intestinal permeability were 0. 38,0. 29,0. 37 cm.min ~. CONCLUSION Yuquan Pill may compete the routes of intestinal absorption with metformin, and the absorption of metformin by small intestine in rats is inhibited Yuquan Pill.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第4期292-294,共3页
Chinese Journal of Hospital Pharmacy
关键词
盐酸二甲双胍
玉泉丸
单向灌流法
在体肠吸收
metformin
Yuquan Pill
single-pass intestinal perfusion
in vivo intestine absorption
