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抗类风湿性关节炎新药戈利木单抗 被引量：4

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摘要 戈利木单抗（golimumab）系一种新的人抗肿瘤坏死因子（TNF）单克隆抗体，能与可溶性和跨膜活性形式TNF-α，阻止与TNF受体结合，从而抑制TNF的生物活性。
作者 舒荣 白秋江
机构地区 华北煤炭医学院附属开滦医院
出处 《药物流行病学杂志》 CAS 2011年第1期50-52,共3页 Chinese Journal of Pharmacoepidemiology
关键词 戈利木单抗 类风湿性关节炎 银屑病关节炎 强直性脊柱炎
分类号 R971.1 [医药卫生—药品]
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参考文献12

  • 1McCluggage LK, Scholtz JM. Golimumab: a tumor necrosis factor alpha inhibitor for the treatment of rheumatoid arthritis [ J]. Ann Pharmacother ,2010 ,44( 1 ) : 135-144.
  • 2Campas-Moya C. Golimumab: A novel anti-TNF-alpha hu- man monoclonal antibody for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis [ J ]. Drugs Today (Barc) ,2010,46(1) : 13-22.
  • 3Shealy D, Cai A, Staquet K, et al. Characterization of goli- mumab, a human monoclonal antibody specific for human tumor necrosis factor alpha [ J ]. MAbs,2010, Epub abead of print.
  • 4Zhou H, Jang H, Fleischmann RM, et al. Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis [J]. J Clin Pharma*ol,2007 ,47 ( 3 ) : 383-396.
  • 5Simponi [ EB/OL ]. http : //www. rxlist.com/simponi-drug. htm, 2009-12-09/2010-07-12.
  • 6Xu Z , Vu T , Lee H , et al. Population pharmacokinetics of golimumab, an anti-tumor necrosis factor-alpha human monoclonal antibody, in patients with psoriatic arthritis[ J ]. J Clin Pharmacol,2009,49(9) : 1056-1070.
  • 7Fleischmann R. The efficacy and safety of golimumab in the treatment of arthritis [ J ]. Expert Opin Biol Ther, 2010,10 (7) : 1131-1143.
  • 8Deodhar A, Braun J, Inman RD, et al. Golimumab reduces sleep disturbance in patients with active ankylosing spondyli- tis: Results from a randomized, placebo-controlled trial [ R]. Arthritis Care Res (Hoboken) ,2010-04-01.
  • 9Kavanangh A, Mclnnes I, Mease P, et al. Golimumab, a new human tumor necrosis factor alpha antibody, adminis- tered every four weeks as a subcutaneous injection in psoriat- ic arthritis: Twenty-four-week efficacy and safety results of a randomized, placebo-controlled study [ J ]. Arthritis Rheum, 2009,60(4) : 976-986.
  • 10Keystone EC, Genovese MC, Klareskog L, et al. Golimum- ab, a human antibody to tumour necrosis factor { alpha } giv- en by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study[J]. Ann Rheum Dis,2009, 68(6) : 789-796.

同被引文献128

  • 1杨培增.葡萄膜炎的研究进展[J].中华眼科杂志,2005,41(12):1149-1152. 被引量：39
  • 2全国银屑病流行调查组.全国1984年银屑病流行调查报告[J].中华皮肤科杂志,1986,19:253-261.
  • 3Crane IJ,Forrester JV.Th1and Th2lymphocytes in autoimmune disease[J].Crit Rev Immunol,2005,25(2):75-102.
  • 4Luger D,Caspi RP.New perspectives on effector mechanisms in uveitis[J].Semin Immunopathol,2008,30(2):135-143.
  • 5Diaz-Llopis M,Gallego-Pinazo R,Garcia-Delpech S,Salom-Alonso D.General principles for the treatment of non-infectious uveitis[J].Inflamm Allergy Drug Targ,2009,9(4):260-265.
  • 6Galor A,Margolis R,Brasil OM,Perez VL,Kaiser PK,Sears JE,et al.Adverse events after intravitreal triamcinoline in patients w ith and w ithout uveitis[J].Ophthalmology,2007,114(10):1912-1918.
  • 7Kim TJ,Kim N,Kang HJ,Kim EO,Kim ST,Ahn HS,et al.FK506causes cellular and functional defects in human natural killer cells[J].J Leuk Biol,2010,88(6):1089-1097.
  • 8O’Shea JJ,Ma A,Lipsky P.Cytokines and autoimmunity[J].Nat Rev Im m unol,2002,2(1):37-45.
  • 9Dick AD,Isaacs JD.Immunomodulation of autoimmune responses w ith monoclonal antibodies and immunoadhesins:treatment of ocular inflammatory disease in the next millennium[J].Br J Ophthalm ol,1999,83(11):1230-1234.
  • 10Boyd SR,Young S,Lightman S.Immunopathology of the noninfectious posterior and intermediate uveitis[J].Surv Ophthalm ol,2001,46(3):209-233.

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药物流行病学杂志
2011年 第1期

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