摘要
目的观察芍甘多苷对CCl4亚急性肝损伤大鼠血清转氨酶、肝脏病理及肝脏炎性因子的影响。方法采用CCl4诱发大鼠亚急性肝损伤,然后灌胃给予不同剂量的芍甘多苷治疗,观察药物对血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肝脏组织病理、肝脏一氧化氮(NO)、一氧化氮合酶(NOS)、诱导型一氧化氮合酶(iNOS)及前列腺素F1α(PGF1α)、血栓素B2(TXB2)的影响。结果芍甘多苷对CCl4诱发大鼠亚急性肝损伤升高的转氨酶有明显的降低作用,并使形态学上的肝细胞变性和坏死得到明显改善和恢复,能降低TXB2含量,升高PGF1α/TXB2比值;能降低NO含量和NOS活性。结论芍甘多苷有明显的肝脏保护作用,其机制与降低TXB2,升高PGF1α/TXB2比值,降低NO含量和NOS活性有关。
OBJECTIVE To investigate the protective effect of Shaoganduogan on sermn transaminase, liver pathology, hepatocyte inflammatory factors in subacute liver injury rat induced by carbon tetrachloride. METHODS Subacute liver injury of rats was induced by carbon tetrachloride, then was treated by different doses of Shaoganduogan through intragastric administration. Serum ALT, AST, liver pathology, and NO, NOS and TXA2. PGI2 in liver. RESULTS Shaoganduogan could remarkably reduce the activity of transaminase, alleviate the pathologic change, reduce the levels of NO, TXB2 and activity of NOS, increase the ratio of PGF1α/TXB2. CONCLUSION Shaoganduogan has significant liver protection effect, and its mechanism is related with reducing the levels of NO, TXB2 ,and NOS activity, also with increasing the ratio of PGF1α/TXB2.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2011年第4期266-269,共4页
Chinese Pharmaceutical Journal
基金
国家十五科技攻关计划项目(2001BA701A07-22)
四川省重大科技招标项目(编号:01SG003-33)
关键词
芍药甘草汤
芍甘多苷
肝脏保护
机制
paeornia and glycyrrhiza decoction
Shaoganduogan
liver protection
mechanism
