4Priyamvada Acharya, Eerappa Rajakumara, Rajah Sankaranarayanan, et al. Structural basis of selection and thermostability of laboratory evolved Bacillis subtilis lipase[J]. J Mol Biol, 2004,341(5) :1271 - 1281.
5Jochen Hecky and Kristian M. Muller. Structural perturbation and compensation by directed evolution at physiological temperature leads to thermostabi- lization of beta - lactamase[J]. Biochemistry, 2005,44(38) : 12640 - 12654.
6Oliver Spadiut, Christian l.eitner, Clara Salaheddin, et al. Improving thennostability and catalytic activity of pyranose 2 - oxidase from Trametes multicolor by rational and semirational design[J]. FEBS Journal, 2009,276 (3) :776 - 92.
7Jaeger K E,Reetz M T.Trends Biotechnol,1998,16:396
