期刊文献+

曲前列环素治疗肺动脉高压的有效性及安全性 被引量:1

原文传递
导出
摘要 国外试验证实,曲前列环素治疗肺动脉高压是有效,安全及可耐受的。国外众多的关于曲前列环素临床药物试验(不同的给药方式,如静脉,皮下及吸入等),证实曲前列环素能显著改善肺动脉高压患者运动耐量、症状及血流动力学,疗效与依前列醇相似但潜在危及生命的不良反应较少,同时可以用于波生坦及西地那非等口服效果不理想的患者。曲前列环素是一种治疗肺动脉高压的有效药物,部分代替静脉输注曲前列环素是可行性,同时可以用于波生坦、西地那非等口服药物治疗症状改善无明显的肺动脉高压患者。
出处 《临床药物治疗杂志》 2011年第1期45-47,共3页 Clinical Medication Journal
  • 相关文献

参考文献13

  • 1Simonneau G,Barst RJ,Galie N,et al.Continuous subcutaneous infusion of treprostinil,a prostacyclin analogue,in patients with pulmonary arterial hypertension:a double-blind,randomized,placebo-controlled trial[J].Am J Respir Crit Care Med,2002,165,800-804.
  • 2Vachiery JL,Hill N,Zwicke D,et al.Transitioning from i.v.epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension[J].Chest,2002,121,1561-1565.
  • 3Rubenfire M,McLaughlin VV,Allen RP,et al.Transition from intravenous epoprostenol to subcutaneous treprostinil in pulmonary arterial hypertension:a controlled trial[J].2007,1 32,757-763.
  • 4Lang I,Gomez-Sanchez M,Kneussl M,et al.Efficacy of longterm subcutaneous treprostinil sodium therapy in pulmonary hypertension[J].Chest,2006,129,1636-1643.
  • 5Barst R J,Galie N,Naeije R,et al.Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil[J].Eur Respir J,2006,28,1195-1203.
  • 6D' Alonzo GE,Barst RJ,Ayres SM,et al.Survival in patients with primary pulmonary hypertension.Results from a national prospective study[J].Ann Intern Med,1991,115,343-349.
  • 7Laliberte K,Arneson C,Jeffs R,et al.Pharmacokinetics and steady-state bioequivalence of treprostinil sodium (Remodulin) administered by the intravenous and subcutaneous route to normal volunteers[J].J Cardiovasc Pharmacol,2004,44,209-214.
  • 8Tapson VF,Gomberg-Maitland M,Mclaughlin VV,et al.Safety and efficacy of Ⅳ treprostinil for pulmonary arterial hypertension:aprospective,multicenter,open-label,12-week trial[J].Chest,2006,129,683-688.
  • 9Gomberg-Maitland M,Tapson VF,Benza RL,et al.Transition from intravenous epoprostenol to intravenous treprostinil in pulmonary hypertension[J].Am J Respir Crit Care Med,2005,172,1586-1589.
  • 10Sitbon O,Manes A,Jais X,et al.Rapid switch from intravenous epoprostenol to intravenous treprostinil in patients with pulmonary arterial hypertension[J].J Cardiovasc Pharmacol,2007,49,1-5.

同被引文献14

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部