摘要
目的探讨PTEN和HIF-1α蛋白在肺癌组织中表达的临床病理意义。方法应用免疫组织化学SP法检测99例肺癌组织中PTEN和HIF-1α蛋白的表达状况。结果 99例肺癌中,PTEN和HIF-1α蛋白的总阳性率分别为62.63%和56.57%;在伴淋巴结转移组和淋巴结无转移组,PTEN蛋白的阳性率分别为51.85%和75.56%,组间比较,差异有统计学意义(χ2=5.89,P<0.05),而HIF-1α蛋白在两组间的表达差异无统计学意义(χ2=0.35,P>0.05);Ⅰ-Ⅱ期肺癌组PTEN蛋白的表达67.05%,Ⅲ-Ⅳ期肺癌组为27.27%,组间比较,差异有统计学意义(χ2=5.02,P<0.05);而Ⅰ-Ⅱ期肺癌组HIF-1α蛋白的表达为52.27%,Ⅲ-Ⅳ期肺癌组为90.91%,组间比较,差异有统计学意义(χ2=4.47,P<0.05);PTEN蛋白表达均与HIF-1α蛋白表达呈负相关(r分别=-0.37、-0.42,P均<0.05)。结论 PTEN和HIF-1α蛋白在肺癌中的异常表达可能在肺癌的恶性演进中起重要作用。
Objective To study the PTEN and HIF-1α proteins expression and their clinical significance in the lung cancer tissues.Methods Immunohistocheemical methods were used to detect the expression of PTEN and HIF-1α proteins in 99 cases of lung cancer tissues.Results The positive rates of PTEN and HIF-1α proteins were 62.63% and 56.57% respectively in the lung cancer tissues.The positive rates of PTEN protein were 51.85% and 75.56% in the groups of positive lymph node metastasis and non-lymph node metastastasis,the difference was significant（χ2=5.89,P0.05）.While there was no significant differences of HIF-1α protein between them（χ2=0.35,P0.05）.The higher positive rate（67.05%） of PTEN protein was obtained in the group of stage Ⅰ,Ⅱ than that（27.27%） in the group of stage Ⅲ,Ⅳ（χ2=5.02,P0.05）.The lower positive rate（52.27%） of HIF-1α protein was obtained in the group of stage Ⅰ,Ⅱ than that（90.91%） in the group of stage Ⅲ,Ⅳ（χ2=4.47,P0.05）.PTEN protein expression was negatively associated with HIF-1α protein expression（r =-0.37,-0.42,P0.05）.Conclusions Extremely expression of the PTEN and HIF-1α proteins might play an important role in the pathogenesis and progression in lung cancer.
出处
《全科医学临床与教育》
2011年第1期8-10,共3页
Clinical Education of General Practice
