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脂联素对大鼠心肌缺血再灌注损伤的保护研究 被引量：2

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摘要 脂联素是近年来发现的一种由脂肪组织分泌的细胞因子,具有调节糖脂代谢、抗炎、抗动脉粥样硬化等作用。本实验以缺血再灌注大鼠为模型,观察给予外源性脂联素对大鼠心肌缺血再灌注后肌酸激酶、乳酸脱氢酶（LDH）含量的影响及对再灌注后大鼠心肌功能的保护性作用,并探讨其作用的机制,从而为临床治疗提供有效的实验依据。
作者 陈君 边云飞 刘钊 肖传实
机构地区 山西医科大学第二医院心内科
出处 《中国药物与临床》 CAS 2011年第2期154-155,共2页 Chinese Remedies & Clinics
关键词 心肌缺血再灌注损伤 保护性作用 脂联素 大鼠 抗动脉粥样硬化 乳酸脱氢酶 细胞因子 脂肪组织
分类号 R541 [医药卫生—心血管疾病]
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参考文献8

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同被引文献33

  • 1蔡庆勇,梁贵友,牛义民,高振宇,宋宣统.体外循环心肌胰岛素抵抗的实验研究[J].合肥医学院学报,2006,29(4):347-350. 被引量：15
  • 2Yang Z, Bert S S, Gilson W D, et al. Simultaneous evaluation of infarct size and cardiac function in intact mice by contrast-en- hanced cardiac magnetic resonance imaging reveals Contractile dys- function in noninfarcted regions early after myocardial infarction [J]. Circulation, 2004,109(9) :1161 -7.
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  • 6Liang,G Y, Cai Q Y, Niu Y M, et al. Cardiac glucose uptake and suppressed expression/translocation of my- ocardium glucose transport-4 in dogs undergoing ische- mia-reperfusion[J]. Experimental Biology and Medi- cine, 2008,233 ; 1142-1148.
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  • 8Bin Liu,Guiyou Liang, Gang Xu,et al. Intervention of rosiglitazone on myoeardium Glut4-mRNA expression during ischemia-reperfusion injury in cardiopulmonary bypass in dogs[J]. Mol Cell Biochem, 2013,373 ( 1 ) 279-284.
  • 9Morrison A, Yan X, Tong C,et al. Acute rosiglita-zone treatment is cardioprotective against ischemia- reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice[J]. Am J Physiol Heart Circ Physiol,2011,301:895-902.
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中国药物与临床
2011年 第2期

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