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表皮生长因子对动物肠道健康的影响 被引量：3

Effect of Epidermal Growth Factor on Gastrointestinal Health of Animals
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摘要 表皮生长因子是一种重要的肽类物质,因具有特殊生理功能而逐渐成为当今研究的一道亮点。本文主要综述了EGF对动物肠道黏膜机械屏障、化学屏障和免疫屏障的影响,阐述了EGF对动物肠道分泌、消化和吸收功能的影响,从而探讨EGF对肠道健康的保护作用及其可能的作用机制,同时讨论了研究中存在的一些问题。 Epidermal growth factor （EGF） is a substaintial peptides. For its special physiological function, more and more researchers put emphasis on it. In this article, the effect of EGF on mechanical barrier, chemical barrier and immunologic barrier of intestinal tract mucous membrane were mainly summarized. It was also expounded that the effect of EGF on the secretion, digestion and absorptive function of intestinal tract. The protective effect of EGF on the health of intestinal tract and the possible mechanism of its function were reviewed. The problems present in the previous researches were also discussed.
作者 吴秀群 王辉 贾刚 王康宁
机构地区 四川农业大学动物营养研究所
出处 《云南农业大学学报（自然科学版）》 CAS CSCD 北大核心 2011年第1期110-116,共7页 Journal of Yunnan Agricultural University:Natural Science
基金 四川省杰出青年学术技术带头人资助计划(2010JQ0043)
关键词 表皮生长因子 肠道健康 黏膜屏障 epidermal growth factor mucous membrane mucous membrane barrier
分类号 Q483 [生物学—生理学]
  • 相关文献

参考文献45

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二级参考文献24

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共引文献16

同被引文献50

  • 1乐志培.表皮生长因子的受体功能与转化蛋白的关系[J].生命的化学,1989,9(2):9-12. 被引量：10
  • 2杨彩梅,徐卫丹,陈安国.甘氨酰-L-谷氨酰胺对断奶仔猪生长性能及肠道吸收功能的影响[J].中国畜牧杂志,2005,41(8):6-8. 被引量：34
  • 3曹德瑞,邹晓庭.日粮添加谷氨酰胺对断奶仔猪小肠形态结构的影响[J].中国饲料,2007(14):18-20. 被引量：9
  • 4Cohen S. Isolation of a mouse submaxillary gland protein accel-erating incisor eruption and eyelid opening in the newborn ani-mal[J]. J Biol Chem, 1962,237(5) :1555-1562.
  • 5Pillai S B,Hinman C E,Luquette M H,et al. Heparin-blindingepidermal growth factor-like growth factor protects rat intes-tine from ischemia/reperfusion injury[J]. J Surg Res,1999,87(2):225-231.
  • 6Carpenter G, Cohen S. Epidermal growth factor [J ]. J BiolChem, 1990,265(14) :7709-7712.
  • 7Dvorak B,Kolinska J, Mcwilliam D L. ,et al. The expression ofepidermal growth factor and transforming growth factor-a mR-NA in the small intestine of suckling rats:organ culture study[J]. FEBS Lett,1998,435(1):119-124.
  • 8Banan A,Farhadi A, Fields J Z,et al. Evidence that nuclear fac-tor-kappa B activation is critical in inactivation is essential inepidermal growth factor-mediated protection of the monolayersof intestinal epithelia [ J]. J Pharmacol Exp Ther, 2003,306?1):13-28.
  • 9Xu H,Collins J F,Bai L Q,et al. Epidermal growth factor reg-ulation of rat NHE2 gene expression [J]. Am J Physiol CellPhysioU2001,281(2) :C504-C513.
  • 10Dvorak B, Halpern M D, Hana H, et al. Epidermal growthfactor reduce the development of necrotizing enterocolitis in aneonatal rat model[J]. Am J Physiol Liver Physiol, 2002 , 282(1):G156-G164.

引证文献3

二级引证文献4

云南农业大学学报（自然科学版）
2011年 第1期

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