摘要
本文研究了红竹菌素与氯气的反应 ,发现经过氯代修饰后的竹红菌素氯代产物具有更好的吸光能力及更高的光动力活性和光稳定性 ,是一类更好的新型光敏化剂。化合物 C是竹红菌素的七员环上脱乙酰基后的产物 ,经研究 ,结果与 HA和 HB相对应。
HA is used first in China as phototherapautic agent and sensitizers and shows curative effect in treating manifold persistent dermatoses.In order to obtain new serious sensitizers of HA we study the chlorination of HA and obtain the chloroproducts of HA,in which the protons of perylene quinone are singley or double substitutde by chlorine atom.There is not noly the classical etectrophllic substitution but also the free radical reaction taken place in the chiorination of HA.The chloroproducts of HA will be the new sensitizers and photothera pautic agents of better properties,because their wavelenth are longer utilization ratios of light are higer than HA.We also study the chlorinations of HB and C,two derivatives of HA.Their results are similar with HA.
出处
《天然产物研究与开发》
CAS
CSCD
1999年第3期27-32,共6页
Natural Product Research and Development
基金
国家自然科学基金资助项目&&
关键词
竹红菌素
光动力活性
光敏化剂
氯代反应
Hypocrellin,chlorination of perylene quinone,chloroproducts of Hyporcrellin,phototherapautic agent,The motive force active of light
