摘要
目的:探讨认知矫正治疗对精神分裂症恢复期患者的影响。方法:对86例精神分裂症恢复期患者随机分为认知矫正治疗组与对照组,每组43例,采用神经认知矫正手册(汉化)为治疗工具,认知矫正治疗组患者进行认知作业练习24周。对照组予以一般工娱活动。在治疗前后,两组患者分别进行社会功能缺陷筛选量表(SDSS)、简明精神病量表(BPRS)、威斯康星卡片测验(WCST)评定。结果:24周后每组各脱落3例。①治疗后治疗组患者SDSS总分较治疗前有明显下降(t=5.33,P<0.05);较对照组有显著差异(t=2.16,P<0.05);②治疗后WCST评分比较,治疗组患者较治疗前,正确反应数明显增加(t=2.56,P<0.05),持续错误反应数明显减少(t=4.71,P<0.05);治疗前后两组间比较,差异均无统计学意义(P均>0.05);③以SDSS总分为自变量,WCST中正确反应数、持续错误反应数、分类数为因变量,逐步回归分析显示,治疗前以及治疗后WCST与SDSS所拟合的回归方程具有统计学意义(F=36.84,P<0.05)。其中,持续错误反应数与SDSS总分呈明显线性相关关系。结论:认知矫正治疗能明显改善精神分裂症患者认知缺陷和社会功能,精神分裂症患者认知缺陷的恢复水平影响着患者社会功能的改善程度。
Objective： To explore the effects of cognitive remediation therapy on patients with schizophrenia. Method：86 remitted patients with schizophrenia were randomly assigned to either therapy group （n=43） receiving cognitive remediation treatment or control group （n=43） receiving common treatment for 24 weeks.Social disability screening schedule （SDSS）,brief psychiatric rating scale （BPRS） and Wiscosin card sorting test （WCST） were administered to all subjects at pre-and post-treatment. Results：Three patients of each group dropped at the endpoint.①After treatment,the therapy group showed significant decrease （t=5.33,P0.05）,and more decrease in SDSS score （t=2.16,P0.05） than control group.②Of WCST,the correct responses was significantly increased （t=2.56,P0.05）,and persistent error responses was significantly declined （t=4.71,P0.05） in the therapy group after treatment.No significant differences were found between two groups at pre-and post-treatment （all P0.05）.③Regression analysis was conducted with SDSS total score as the independent variable and correct responses,persistent error responses and categories completes of WCST as the dependent variable.The correct responses,persistent error responses and categories completes entered the regression equation at pre-treatment,while the persistent error responses entered the regression equation at post-treatment.The persistent error responses were positively correlated with SDSS score. Conclusion：The cognitive remediation treatment can improve cognitive function and social function of patients with schizophrenia.The cognitive function restoration can predict social function improvement in remitted patients with schizophrenia.
出处
《临床精神医学杂志》
2011年第1期15-17,共3页
Journal of Clinical Psychiatry
基金
苏州市科技局计划性课题(130328)
关键词
精神分裂症
认知矫正治疗
认知缺陷
社会功能
schizophrenia
cognitive remediation therapy
cognitive impairment
social function
