摘要
目的:观察甲泼尼龙联合雾化肾上腺素治疗Ⅲ度喉梗阻的疗效。方法:治疗组22例喉炎合并Ⅲ度喉梗阻患儿,应用小剂量甲泼尼龙静脉注射联合氧气驱动雾化吸入肾上腺素治疗。对照组给予静脉注射地塞米松,同时雾化吸入地塞米松治疗。两组均辅以抗生素等治疗。结果:入院经治疗1 h后,治疗组22例患儿缺氧症状均得到改善,有效率100%,对照组3例病情好转,有效率仅为15.0%。治疗2 h后,治疗组有效率100%,对照组有效率65.0%。两组疗效比较差异有统计学意义(P<0.05)。结论:小剂量甲泼尼龙联合雾化吸入肾上腺素治疗Ⅲ度喉梗阻起效快,疗效明显优于单纯用地塞米松静脉注射并同时吸入地塞米松,且不良反应小,可避免气管切开。
Objective：To observe the efficacy in the treatment of degree Ⅲ laryngeal obstruction with methylprednisolone combined with nebulized epinephrine.Methods： Twenty two children of acute laryngitis with degree Ⅲ laryngeal obstruction in observation group used a small dose of intravenous methylprednisolone combined with inhalation of oxygen-driven nebulized epinephrine.Twenty children in the control group used intravenous and synchronously nebulized dexamethasone.Both groups received antibiotics as adjunctive therapy at the same time.Results： After one hour＇s treatment,in the observation group,all children＇s hypoxia symptoms improved with a 100% effective rate.While in the control group,only three children＇s hypoxia symptoms improved with a 15.0% effective rate.After two hours of treatment,the effective rate in control group was raised to 65.0%.The difference between the efficacy of the two groups was statistically significant（P0.05）.Conclusions： The treatment of degree Ⅲ laryngeal obstruction with a small dose of methylprednisolone combined with inhalation of nebulized epinephrine is effective and can avoid a tracheotomy.The efficacy of the treatment is obviously higher than intravenous and synchronously nebulized dexamethasone.
出处
《儿科药学杂志》
CAS
2011年第1期36-38,共3页
Journal of Pediatric Pharmacy
关键词
甲泼尼龙
肾上腺素
喉梗阻
Methylprednisolone
Epinephrine
Laryngeal obstruction
