摘要
目的 为了探讨ＣＤ４４Ｖ３和ＣＤ４４Ｖ６ 在非小细胞肺癌组织中的表达及预后意义。方法应用免疫组织化学链菌素抗生物素蛋白过氧化物酶连接法（Ｓ－ Ｐ法），对６２ 例有５ 年随访资料的非小细胞肺癌组织进行了ＣＤ４４Ｖ３ 和ＣＤ４４Ｖ６ 蛋白的检测。结果 非小细胞肺癌的ＣＤ４４Ｖ３ 和ＣＤ４４Ｖ６ 阳性表达率分别为６６．１％ 和６７．７％ ，皆与肿瘤病理分级及组织学类型无明显相关性；ＣＤ４４Ｖ３ 和ＣＤ４４Ｖ６阳性表达与非小细胞肺癌临床分期、淋巴结转移有显著相关性；非小细胞肺癌的ＣＤ４４Ｖ３ 和ＣＤ４４Ｖ６ 阳性表达在１ 年、３ 年术后生存率分别与５ 年比较有显著意义；结果还表明ＣＤ４４Ｖ３ 和ＣＤ４４Ｖ６ 阳性表达率与肿瘤大小有关，肿瘤直径＞ ３ｃｍ 者明显高于肿瘤直径≤３ｃｍ 者（Ｐ＜ ０．００５）。结论 在非小细胞肺癌中，ＣＤ４４Ｖ３ 和ＣＤ４４Ｖ６阳性表达提示容易发生淋巴结转移，多见于晚期肺癌，预后较差。ＣＤ４４Ｖ３和ＣＤ４４Ｖ６可作为临床评估非小细胞肺癌进展的辅助指标之一。
? Objective To study the expressions of CD44V3 and CD44V6 in non small cell lung carcinoma(NSCLC) and their significance in prognosis.Methods 62 Cases who have been followed up for five years were investigated to detect the expressions of CD44V3 and CD44V6 by immunohistochemistry(S-P method).Results The positive expression rates of CD44V3 and CD44V6 in NSCLC were 66.1% and 67.7% respectively and were not correlated with various histologic types and pathologic grades;The results showed that CD44V3 and CD44V6 positive expressions were associated with clinical stages and lymphaden metastasis;One and three year survival rates of postoperation with CD44V3 and CD44V6 postive expression compared with five year survival rate respectively were significantly different;The results also showed that CD44V3 and CD44V6 positive expressions were correlated with tumor size,CD44V3 and CD44V6 positive expression rates were higher in tumor >3cm diameter than that in tumor≤3cm diameter(P<0.005).Conclusion The results suggest that CD44V3 and CD44V6 positive expressions are likely to develope lymphatic metastasis and result in poor prognosis in NSCLC.CD44V3 and CD44V6 are considered as one of the indicators for evaluating the progression of lung carcinoma. 〔
出处
《中国肿瘤临床与康复》
1999年第4期24-27,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
