摘要
One dinuclear complex [Cu2Cl2（HEMDP） 2]·THF 1（H2EMDP = 2-[（2-hydroxyethylimino）-methyl]-4,6-diiodo-phenol,THF = tetrahydrofuran） has been designed and synthesized by H2EMDP with CuCl2·2H2O in THF solvent. Complex 1 was characterized by UV,IR,ESI-MS,and elemental analyses. 1 was characterized by X-ray crystallography. The crystal belongs to the monoclinic system,space group C2/c with a = 27.886（3） ,b = 8.6890（12） ,c = 26.698（2）A,β = 105.521（2） o,V = 6233.1（12）A^3,Z = 8,Mr = 1102.01,μ = 5.533 mm^-1,Dc = 2.349 Mg/m^3,F（000） = 4112,the final R = 0.0486 and wR = 0.1175（I 〉 2σ（I）） . In addition,further investigation revealed that the central copper（Ⅱ） atom in the complex is five-coordinated by one nitrogen atom and two oxygen atoms from H2EMDP and two chlorine atoms from chlorid. The 3,5-diiodosalicylaldehyde Schiff base acts as a tridentate ligand. H2EMDP and 1 were assayed for antibacterial（B. subtilis,S. aureus,S. faecalis,P. aeruginosa,E. coli and E. cloacae） activities by MTT（3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl trtrazolium bromide） method. 1 showed the most favorable antimicrobial activity with MICs of 3.125,6.25,6.25,12.5,3.125 and 6.25 μg/mL against B. subtilis,S. aureus,S. faecalis,P. aeruginosa,E. coli and E.cloacae,respectively.
One dinuclear complex [Cu2Cl2（HEMDP） 2]·THF 1（H2EMDP = 2-[（2-hydroxyethylimino）-methyl]-4,6-diiodo-phenol,THF = tetrahydrofuran） has been designed and synthesized by H2EMDP with CuCl2·2H2O in THF solvent. Complex 1 was characterized by UV,IR,ESI-MS,and elemental analyses. 1 was characterized by X-ray crystallography. The crystal belongs to the monoclinic system,space group C2/c with a = 27.886（3） ,b = 8.6890（12） ,c = 26.698（2）A,β = 105.521（2） o,V = 6233.1（12）A^3,Z = 8,Mr = 1102.01,μ = 5.533 mm^-1,Dc = 2.349 Mg/m^3,F（000） = 4112,the final R = 0.0486 and wR = 0.1175（I 〉 2σ（I）） . In addition,further investigation revealed that the central copper（Ⅱ） atom in the complex is five-coordinated by one nitrogen atom and two oxygen atoms from H2EMDP and two chlorine atoms from chlorid. The 3,5-diiodosalicylaldehyde Schiff base acts as a tridentate ligand. H2EMDP and 1 were assayed for antibacterial（B. subtilis,S. aureus,S. faecalis,P. aeruginosa,E. coli and E. cloacae） activities by MTT（3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl trtrazolium bromide） method. 1 showed the most favorable antimicrobial activity with MICs of 3.125,6.25,6.25,12.5,3.125 and 6.25 μg/mL against B. subtilis,S. aureus,S. faecalis,P. aeruginosa,E. coli and E.cloacae,respectively.
基金
supported by the National Natural Science Foundation of China (No.30772627)
Natural Science Foundation of Jiangsu Province (No.09KJD150005)
