摘要
目的： 了解Ⅰ、Ⅲ型前胶原基因在增生性瘢痕（ Ｈ） 和瘢痕疙瘩（ Ｋ） 组织中表达的空间分布。方法： 非同位素原位杂交。结果： Ｋ 与 Ｈ 组织中Ⅰ型前胶原ｍ Ｒ Ｎ Ａ 表达均增强， Ｈ 中呈弥散分布， 而 Ｋ 中却主要位于网状真皮层的上部； Ⅲ型前胶原ｍ Ｒ Ｎ Ａ 表达增强仅见于 Ｈ 中。结论： Ｋ 和 Ｈ 组织中胶原蛋白基因表达强度及空间分布的差异可能是两者不同临床表现及生物学行为的分子病理学基础。
Objective:To study the space distribution of expression of mRNA for typeⅠand Ⅲ in keloid and hypertrophic scars. Method:Non isotope in situ hybridization. Result: The mRNA expression of typeⅠprocollagen in tissues increased, which being diffusely distributed in hypertrophic scar, but mainly localizing the upper of reticular dermo layer in keloid. However, only the increasing of mRNA expression of type Ⅲ procollagen existed in hypertrophic scar. Conclusion: The difference on the expression intensity and space distribution for collagen gene perhaps was a base of moleclular pathology of various clinical manifestation and biological behavior.
出处
《汕头大学医学院学报》
1999年第2期11-13,共3页
Journal of Shantou University Medical College
关键词
增生性瘢痕
瘢痕疙瘩
原位杂交
胶原蛋白
表达
Hypertrophic Scar
Keloid
In site Hybridization
Collagen
mRNA Expression
