RNA干扰技术给药途径的研究进展

暂未订购

导出

摘要 RNA干扰（RNAi）是序列特异性双链RNA（dsRNA）介导的基因沉默机制,这种机制将有希望成为治疗多种疾病的有力工具。Castanotto和Rossi[1]在新杆状线虫中发现双链RNA有沉默基因表达的能力。

作者张海涛李郑武王莹张秀芹郭长虹李会成

机构地区哈药集团技术中心哈尔滨师范大学生命科学与技术学院

出处《重庆医学》 CAS CSCD 北大核心 2011年第5期495-497,共3页 Chongqing medicine

基金黑龙江省自然科学基金资助项目(ZJY04-06) 黑龙江省哈尔滨市科技攻关计划项目(2005AA3BS091)

关键词 RNA 病毒载体蛋白质类 RNAI

参考文献32

1Castanotto D,Rossi JJ.The promises and pitfalls of RNA-interference-based therapeutics[J].Nature,2009,457(7228):426-433.
2Nguyen T,Menocal EM,Harborth J,et al.RNAi therapeutics:an update on delivery[J].Curr Opin Mol Ther,2008,10(2):158-167.
3Hannon GJ,Rossi JJ.Unlocking the potential of the human genome with RNA interference[J].Nature,2004,431(7006):371-378.
4Check EA.Crucial test[J].Nature Med,2008,11(3):243-244.
5McFarland TJ,Zhang Y,Appukuttan B,et al.Gene therapy for proliferative ocular diseases[J].Expert Opin Biol Ther,2004,4(7):1053-1058.
6Bitko V,Musiyenko A,Shulyayeva O,et al.Inhibition of respiratory viruses by nasally administered siRNA[J].Nature Med,2005,11(1):50-55.
7Rossi JJ.RNAi as a treatment for HIV-1 infection[J].Biotechniques,2006,40:25-29.
8Dykxhoorn DM,Lieberman J.Silencing viral infection[J].Plo S Med,2006,3:242.
9Raoul C,Barker SD,Aebischer P.Viral-based modeling and correction of neurodegenerative diseases by RNA interference[J].Gene Ther,2006,13:487-495.
10Pai SI,Lin YY,Macaes B,et al.Prospects of RNA interference therapy for cancer[J].Gene Ther,2006,13(6):464-477.

1Dasika GK,Lin SC,Zhao S,et al.DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis[J].Oncogene,1999,18:7883.
2Olsen JH,Hahnemann JM,Borresen Dale AL,et al.Cancer in patients with ataxia-telangiectasia and in their relatives in the nordic countries[J].J Natl Cancer Inst,2001,93(2):121.
3Grebaek K,Worm J,Ralfkiaer E,et al.ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma[J].Blood,2002,100(4):1430.
4Iliakis G,Wang Y,Guan J,et al.DNA damage checkpoint control in cells exposed to ionizing radiation[J].Oncogene,2003,22:5834.
5Willers H,Dahm-Daphi J,Powell SN.Repair of radiation damage to DNA[J].Br J Cancer,2004,90:1297.
6Sarkaria JN,Eshleman JS.ATM as a target for novel radiosensitizers[J].Semin Radial Oncol,2001,11(4):316.
7Lee SR,Collins K.Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs[J].Nat Struct Mol Biol,2007,14(7):604.
8Wang JZ,Li XA,Souza WD,et al.Impact of prolonged fraction delivery times on tumor control:a note of caution for intensity-modulated radiation therapy(IMRT)[J].Int J Radiat Oncol Biol Phys,2003,57(2):543.
9李高峰,陈龙华.ATM在肿瘤放射增敏治疗中的研究进展[J].重庆医学,2007,36(21):2224-2226. 被引量：3

重庆医学

2011年第5期

内容加载中请稍等...