摘要
目的探讨肿瘤坏死因子-α(TNF-α)与抗炎细胞因子——可溶性肿瘤坏死因子受体-1(sTNF-1R)、白细胞介素-10(IL-10)在急性胰腺炎中的变化及意义。方法对26例轻症胰腺炎(MAP组)、22例重症胰腺炎(SAP组)患者分别于入院第1、4、7、14天进行血清TNF-α、sTNF-1R及IL-10的检测。同时设立30例健康体检者为对照组,并对以上数据进行统计学处理。结果两组患者血清TNF-α、sTNF-1R、IL-10水平均在第1天达到高峰,然后逐步下降。MAP组血清TNF-α水平在第7天降至对照组水平,SAP组在第14天才降至对照组水平,而SAP组血清TNF-α水平在第1、4、7天水平远高于MAP组(P<0.01)。两组sT-NF-1R水平变化趋势与TNF-α相似,但第14天SAP组sTNF-1R仍维持较高水平。第1天MAP组血清IL-10水平远高于SAP组(P<0.01)。结论 TNF-α与sTNF-1R、IL-10均参与了急性胰腺炎的炎症反应过程,可以作为临床预测胰腺炎严重程度的指标。
Objective To observe the changes and significance of tumor necrosis factor-α（TNF-α）,soluble tumor necrosis factor recepter-1（sTNF-1R）,interleukin-10（IL-10） in acute pancreatitis.Methods The 26 patients with mild acute pancreatitis（MAP group） and 22 patients with severe acute pancreatitis（SAP group） were measured the degree of TNF-α,sTNF-1R,IL-10 at 1,4,7,14 d by ELISA.Meanwhile,the 30 healthy patients were control group.Results In both MAP group and SAP group,serum TNF-α,sTNF-1R,IL-10 were approached the peak at the first day,then decreased gradually.In SAP group,serum TNF-α was significantly higher than those in MAP group at 1,4,7 d（P0.01）.Serum TNF-α in MAP decreased to the level of control group 7 days later,while those in SAP decreased to the level of control group 14 days later.Serum sTNF-1R has a similar trend as TNF-α in both MAP and SAP group.Differently,serum sTNF-1R in SAP group still keep high level 14 days later.Serum IL-10 in MAP group was significantly higher than those in SAP group at first day（P0.01）.Conclusion TNF-α,sTNF-1R and IL-10 play important roles in the development of acute pancreatitis,and they may be valuable indexes to predict the severity of acute pancreatitis.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第5期433-434,437,共3页
Chongqing medicine
