摘要
目的观察脐带间充质干细胞输注治疗遗传性痉挛性截瘫(Hereditary Spastic Paraplegia,HSP)的疗效和安全性。方法将细胞总数为(2-6)×107个脐带间充质干细胞通过静脉输注和腰穿鞘内注射到自愿接受干细胞治疗的2例HSP患者体内。术后随访1年余,定期观察患者临床症状及各项指标的变化并进行综合分析。结果脐带间充质干细胞治疗后2例患者临床症状均明显好转:双下肢肌张力明显降低,不需借助拐杖或他人帮助可独立行走且步态平稳,治疗后各项生化指标正常,未出现严重的并发症和明显的不良反应。随访1年余,2例患者的症状持续缓解无复发。结论脐带间充质干细胞治疗HSP近期疗效明显,可以改善患者的临床症状,延缓病情进展,是一种值得借鉴的治疗方法。
Objective To observe the clinical effect and safety of umbilical cord mesenchymal stem cells（UC-MSC） infusion in treatment of hereditary spastic paraplegia（HSP）.Methods Two patients with HSP were infused with（2-6）×107 UC-MSC through the vein or injected into the sheath by lumbar puncture.The 2 patients were followed up for more than one year after treatment during which their clinical symptoms and various indexes were observed and analyzed.Results The clinical symptoms of patients were obviously improved after infusion of UC-MSC.The muscle tonus of lower extremities was significantly reduced.The patients could walk with stable steps independent of crutches and aid of other persons.Their biochemical indexes became normal with no severe complications and side effects.The patients were followed up for 1 year during which no recurrence occurred.Conclusion Infusion of UC-MSC can achieve rather good short-term outcome in HSP patients by improving their clinical symptoms and delaying the progression of HSP.
出处
《军医进修学院学报》
CAS
2011年第2期184-186,共3页
Academic Journal of Pla Postgraduate Medical School
基金
湖北省青年科技人才基金资助项目~~
关键词
痉挛性截瘫
遗传性
治疗
脐血干细胞移植
Spastic Paraplegia
Hereditary
Therapy
Cord Blood Stem Cells Transpla
