摘要
目的:观察培垛普利联合螺内酯对慢性心力衰竭(CHF)患者心功能和BNP的影响。方法:84例CHF患者随机分为治疗组和对照组,在常规治疗病情基本稳定的基础上,加用培垛普利4 mg,1次/日和螺内酯20 mg,1次/日。观察治疗前后心功能、左室射血分数(EF)、血清脑钠素(BNP)测定及不良反应等。结果:治疗组的心功能疗效总有效率为71.4%,对照组为52.4%;两组患者用药后的左室EF值均较用药前有明显的提高,其提高值治疗组更显著。血清BNP明显下降(P<0.01)。结论:长期应用培垛普利与小剂量螺内酯联合治疗慢性心衰远期临床疗效显著,且使用安全。
To observe the effects of combination using oi perindopril and spironolactone on heart function and brain natriuretic peptide （BNP）of chronic heart failure （CHF）.Methods ： 84 patients with CHF were randomly divided into treatment group and control group. On the basis of conventional therapy, the treatment group was added with perindopril （4 mg once daily） and spironolactone （20 mg once daily）. The heart function ,left ventricle ejection fraction,serum BNP and adverse effects were observed before and after treatment.Results：The total effective rate of heart function in treatment group was 71.4% and 52.4% in control group.Left ventricle ejection fraction of two groups was obviously elevated after treatment, and the increment of treatment group was more significant.Serum BNP was obviously decreased （P〈0.01）.Conclusion：The long-term clinical therapeutic effect of combination using of perindopril and low dose of spironolactone on chronic heart failure is predominant with safe in use.
出处
《现代医药卫生》
2011年第4期517-519,共3页
Journal of Modern Medicine & Health
关键词
培垛普利
螺内酯
慢性心力衰竭
BNP
Perindopril
Spironolactone
Chronic heart failure
Brain natriuretic peptide
