摘要
目的:探讨硝酸咪康唑脂质体的制备工艺。方法:以包封率和载药量为指标,应用正交试验法优选最佳制备工艺。结果:最佳工艺处方为乙醇注入法,药脂比3%(w/w),磷脂与胆固醇的摩尔比为80∶20,缓冲液pH7.4。制备的脂质体包封率为75.54%,平均粒径为222.3 nm,zeta电位为-0.31mV。结论:乙醇注入法制备硝酸咪康唑脂质体包封率高,制备工艺合理、可行。
To study the preparation technology of miconazole nitrate l iposome.Methods：The process technology was optimized through orthogonal design analysis with entrapment efficiency and drug loading as indexes.Results： The method of ethanol injection was chosen as the preferable method,and the ratio of drug to membrane material was 3%（w/w）,the mole ratio of phospholipid to cholesterol was 80：20,pH of the buffer solution was 7.4.For the prepared liposome by optimized formulation and process, the entrapment rate was 75.54%, the average particle size was 222.3nm, and the Zeta potential was -0.3 l mV.Conclusion：The method of ethanol injection has high entrapment rate, and the preparation technology is reasonable and feasible.
出处
《现代医药卫生》
2011年第4期491-492,共2页
Journal of Modern Medicine & Health
基金
西安医学院校级课题(0518)
关键词
硝酸咪康唑
脂质体
制备工艺
正交试验
Miconazole nitrate
Liposome
Preparation technology
Orthogonal design
