摘要
利用不同保护基保护的巯基的氧化反应性不同,分别以空气和碘作为氧化剂,通过选择性氧化工艺使齐考诺肽线性肽的1,8,16,20-位两对Trt保护巯基先形成两对二硫键,然后用碘氧化15,25-位Acm保护的巯基,成功地生成第三对二硫键,合成了齐考诺肽。
Using the different oxidation reactivity of sulfhydryls with different protective group,Ziconotide was synthesized via selective oxidation reaction.Firstly,two disulfide bonds were formatted between the 1,8,16,20-position sulfhydryls protected by Trt in the Ziconotide by air oxidation.Then,the third disulfide bond was formatted between the 15,25-position sulfhydryls protected by Acm with iodine oxidation.
出处
《合成化学》
CAS
CSCD
北大核心
2011年第1期145-147,共3页
Chinese Journal of Synthetic Chemistry
关键词
多肽
二硫键
齐考诺肽
药物合成
peptide
disulfide bonds
ziconotide
drug synthesis
