摘要
以对苄氧基苯酚为原料,经三步反应合成了2-[4-(2-溴乙氧基)苯氧基]乙醇(3);3与1-对甲苯磺酰基哌嗪反应制得4-N-{2-[4-(2-羟乙氧基)苯氧基]乙基}-1-N-对甲苯磺酰基哌嗪(5);在5上引入乙酰巯基后再经碱性水解,合成了新化合物4-N-{2-[4-(2-巯基乙氧基)苯氧基]乙基}-1-N-对甲苯磺酰基哌嗪,其结构经NMR,IR和MS表征。
2-[4-（2-bromoethoxy）phenoxy]ethanol（3） was prepared from 4-（benzyloxy）phenol by a three-step reaction.4-N-{2-[4-（2-hydroxyethoxy）phenoxy]ethyl}-1-N-tosylpiperazine（5） was successfully synthesized by the reaction of 3 with 1-N-tosylpiperazine.Finally,a novel compound,4-N-{2-[4-（2-thioethoxy）phenoxy]ethyl }-1-N-tosylpiperazine,was conveniently obtained by the introduction of the thioacetate group at 5,then by hydrolyzation in the presence of KOH.The structures were characterized by NMR,IR and MS.
出处
《合成化学》
CAS
CSCD
北大核心
2011年第1期52-55,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20872051)
关键词
对苄氧基苯酚
哌嗪
巯基
合成
4-（benzyloxy）phenol
piperazine
thiol
synthesis
