摘要
通过在金鸡纳衍生物的9-OH上引入苄基,合成了四种新型的手性相转移催化剂——金鸡纳生物碱季铵盐(1a～1d),其结构经1H NMR和IR表征。以N-二苯亚甲基甘氨酸叔丁酯为底物考察了1的催化活性和对映选择性,最高产率69%,最佳立体选择性90%ee。
Four new chiral phase transfer catalysts,cinchona alkaloid quaternary ammonium salts（1a～1d）,were synthesised by introduce benzyl into 9-OH of cinchona derivative.The structures were characterized by 1H NMR and IR.The catalytic activity and stereoselectivity of 1 were evaluated using N-（diphenylmethylene）glycine t-butyl ester as a substrate.The highest chemical yields was 69% and the optimal enantioselectivity was 90% ee.
出处
《合成化学》
CAS
CSCD
北大核心
2011年第1期32-35,共4页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20572131)
关键词
生物碱季铵盐
手性
相转移催剂
合成
alkaloid quaternary ammonium salt
chiral
phase transfer catalyst
synthesis
