摘要
目的探讨宫颈液基薄层细胞学技术(TCT)联合阴道镜检查在宫颈病变筛查中的临床应用价值。方法选择2008-01—2010-08河北医科大学第一医院妇科门诊宫颈病变患者570例进行宫颈病变筛查,其中300例行TCT联合阴道镜活检者为实验组,270例直接行阴道镜下取材活检者为对照组。最终以病理组织诊断为标准,比较两组间差异。结果 TCT联合阴道镜下取材行病理组织检查与未经细胞学检查,单一阴道镜下取材活检,两者结果比较,差异有统计学意义(P<0.05)。TCT联合阴道镜检查与病理组织诊断阳性符合率为72.7%(218/300),诊断CIN的特异性87.8%,敏感度48.2%;直接阴道镜下取材活检阳性率为33.0%(89/270),诊断CIN的特异性89.0%,敏感度79.8%。结论采用TCT联合阴道镜检查能较早筛查出宫颈病变,有利于宫颈癌前病变及早期宫颈癌早诊断、早治疗,提高生存率。
Objective To investigate clinical application value of combination of Thinprep Cytology Test（TCT）and vaginoscopy in screening of cervical lesion.Methods Screening of cervical lesion was carried out for 570 cases of patients with suspicious cervical lesion receiving outpatient servicein gynecology department,First Hospital of Hebei Medical University from January,2008 to August,2010.Among them,combination of TCT and biopsy under colposcope was carried out for 300 case（experimental group）and direct biopsy under colposcope was carried out for 270 case（control group）.At last,pathological diagnosis was used as the standard to compare the difference between the two groups.Results There was a significant difference between combination of TCT and vaginoscopy and single biopsy under colposcope（without TCT）（P〈0.05）.The positive compliance rate of combination of TCT and vaginoscopy compared with pathological diagnosis was 72.7%（218/300）.Specificity of CIN diagnosis was 87.8% and its sensitivity was 48.2%.The positive compliance rate of direct biopsy under colposcope was 33.0%（89/270）.Specificity of CIN diagnosis was 89.0% and its sensitivity was 79.8%.Conclusion The combination of TCT and vaginoscopy could earlier screen out cervical lesions and it helped to make early diagnosis and early treatment for cervical precancerous lesion and early cervical cancer and improve the survival rate.
出处
《中国疗养医学》
2011年第2期157-160,共4页
Chinese Journal of Convalescent Medicine
