摘要
目的：观察比较单剂枢复宁联合方案与胃复安联合方案预防大剂量顺铂化疗所致恶心呕吐的疗效。方法：将４９例接受大剂量顺铂化疗的患者随机分为枢联组和胃联组，比较两组急性和迟发性恶心呕吐的控制率。结果：枢联组和胃联组预防急性呕吐的有效率分别为８８％和６０％（Ｐ＜０．０５）；两组预防急性恶心和迟发性恶心、呕吐的有效率均无显著性差异。结论：单剂枢复宁联合方案对急性呕吐的控制效果优于胃联方案，效价比高，值得推广。
Objective:To compare the antiemetic effect of single-dose Zofran combined
with regimen (group A) and metoclopramide combined with regimen (group B) on high-dose
cisplatin chemotherapy.Methods:A randomized,crossover assay was performed in 49 patients
who received high-dose cisplatin chemotherapy to compare the curative effect of these two
therapy programs in the control of acute and delayed emesis.Results:The control rate of acute
vomiting were 88% and 60% in group A and group B respectively ( P <0.05)。Control of acute
nausea and delayed emesis was comparable in these two programs.Conclusion:Single-dose
Zofran combined with regimen is more effective than metoclopramide combined with regimen in
the prevention of high-dose cisplatin-induced acute vomiting.
出处
《中国现代医学杂志》
CAS
CSCD
1999年第7期8-8,11,共2页
China Journal of Modern Medicine
