测定肺泡灌洗液心钠素在肺良恶性病变鉴别中的价值

ANTRIALNATIRETICPEPTIDELEVELOF THEBRONCHOVESICULARIRRIGATEDFLUID INDIFFERENTIATIONBETWEENTHEBENIGNAND MALIGNANTPULMONARYDISORDERS

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摘要目的：探讨支气管肺泡灌洗液（ＢＡＬＦ）心钠素（ＡＮＰ）水平在肺部良、恶性病变鉴别中的价值。方法：采用放射免疫直接测定法，测定４０例肺部良性病变和３５例肺癌患者ＢＡＬＦ中ＡＮＰ水平分别为（７０±６）ｎｇ／Ｌ、（１５３±３５）ｎｇ／Ｌ，两者有极显著差异（Ｐ＜０．００１）；肺良性病变ＢＡＬＦ中ＡＮＰ水平［（７０±６）ｎｇ／Ｌ］明显低于血清ＡＮＰ水平［（１６５±３０）ｎｇ／Ｌ］，差异有极显著性意义（Ｐ＜０．００１）；肺良性病变和肺癌ＢＡＬＦ与血清ＡＮＰ水平之比值分别为０．４２、０．９，两者差异有极显著性意义（Ｐ＜０．００１）；其对肺癌的敏感性及特异性分别为８０％和１００％。结论：测定ＢＡＬＦ中ＡＮＰ水平是肺部良、恶性病变鉴别的重要方法之一。 Objective: InordertostudythevalueofANPlevelofthebronchovesicularirrigatedfluidsindifferentiationbetweenthebenignandmalignantpulmonarydisorders. Methods: TheANPlevelofthebronchovesicularirrigatedfluidsweremeasuredin40patientswithbenigndisordersand35withlungcancerbyradioimmunoassay. Results: ThelevelofANPis706ng/land15335ng/lrespectivelyinthebenignandmalignantpulmonarydisordersandthereisasignificantdifferencebetweenthetwogroups(P<0.001).Amongthepatientswithbenigndisorders,theANPlevelofbronchovesicularirrigatedfluidsislowerthantheleveloftheserum,inwhichisassociatedwithastatisticallysignificance(P<0.001).Aratioofthebronchovesicularfluidsandserumis0.42and0.90inthetwogroupsrespectively(P<0.001).Itssensitivityandspecificitytolungcanceris80%and100%. Conclusion: ThemeasurementofANPlevelofthebronchovesicularirrigatedfluidsisoneoftheimportanttechniquesdifferentiatingthebenigndisordersfrommalignantpulmonarydisorders.