摘要
目的:观察糖尿病合并非瓣膜性心房颤动(AF)患者应用华法林及阿司匹林的疗效。方法:将糖尿病合并非瓣膜性AF患者随机分为华法林组40例,阿司匹林组40例;分析两组血栓栓塞及出血事件。结果:入选非瓣膜性AF患者80例,随访12个月,共发生血栓栓塞事件4例,华法林组1例,阿司匹林组3例,两组差异无统计学意义(P=0.32),发生出血事件5例,华法林组3例,阿司匹林组2例,两组差异无统计学意义(P=0.61)。结论:不具有血栓栓塞的高危因素非瓣膜性AF患者,选择抗血小板药物阿司匹林治疗及抗凝剂华法林疗效及安全性相似。
Objective：To compare the efficacy and safety of warfarin and aspirinin for treating diabetes mellitus（DM） complicating nonvalvular atrial fibrillation（AF）.Methods：According to the 2006 ACC/AHA/ESC clinical guidelines for the management of patients with atrial fibrillation,the patients with DM complicating AF were divided into the warfarin group and the aspirin group.Thromboembolism and bleeding events were compared and analyzed between the two groups.Results：80 patients with nonvalvular AF were chosen,40 cases in each group.The average follow-up period was 12 months.There were 3 thromboembolism events in the aspirin group,but only one in the warfarin group without statistical significance（P=0.32）;there were 3 bleeding events in the warfarin group and 2 in the aspirin group without statisticcal significance（P=0.61）.Conclusion：For nonvalvular AF patients without high-risk of thromboembolism event,the efficacy and safety of warfarin and aspirin are similar.
出处
《现代医药卫生》
2011年第3期343-344,共2页
Journal of Modern Medicine & Health
关键词
心房颤动
糖尿病
华法林
阿司匹林
血栓栓塞
Atrial fibrillation
Diabetes mellitus
Warfarin
Thromboemblism
Aspirin
