摘要
目的：观察放射治疗配合紫杉醇化疗对食管癌的临床疗效。方法：对173例食管癌病人根据不同的治疗方法分为两组：单纯放射治疗组（单放组）和放射治疗同步化疗组（放化疗组）。单放组80例,采用常规设野放疗,DT 65~70 Gy;放化疗组93例,放疗方法及剂量同单放组,化疗采用紫杉醇每周同步方案。两组均随访2年。结果：局部近期疗效放化疗组好于单放组,两组差异有显著性（P〈0.05）。放化疗组与单放组1、2年生存率单放组为51.3%（41/80）、32.5%（26/80）,同步放化组为87%（81/93）、68.8%（64/93）。两组差异有显著性（P〈0.05）。结论：同步放化疗优于单纯放射治疗,可明显提高食管癌的疗效。
Objective：To investigate the effect of radiotherapy combined with paclitaxel on esophageal cancer.Methods：173 cases of esophageal cancer were divided into two groups.The simple radiotherapy group（80 cases） received the conventional radiotherapy with a total of 65～70 Gy,and the concurrent radiochemotherapy group（93 cases） was treated by the radiotherapy with the same method and same dosage plus the chemotherapy with weekly paclitaxel.Both groups were followed up for 2 years.Results：The local and short term effect in the radiochemotherapy group was better than that in the simple radiotherapy group with the statistical difference（P0.05）.The 1-year and 2-year survival rates were 51.3%（421/80） and 32.5%（26/80） in the simple radiotherapy group and 76.3%（71/93） and 58.1%（54/93） in the radiochemotherapy group with statistical difference（P0.05）.Conclusion：Concurrent radiochemotherapy is superior to simple radiotherapy in treating esophageal cancer,which increases the curative effect.
出处
《现代医药卫生》
2011年第1期15-17,共3页
Journal of Modern Medicine & Health
基金
承德市科研指导计划项目(200621040)
关键词
食管癌
化疗后程加速超分割放疗
紫杉醇
Esophageal cancer
Late course accelerated fractionated irradiation
Paclitaxel
