摘要
采用侧脑室给药，以电刺激引起大鼠甩尾反应为指标，测定动物的痛阈。结果显示α干扰素（ＩＦＮα）具有提高大鼠痛阈的作用，其镇痛作用依赖ＩＦＮα剂量，此作用能被抗ＩＦＮα单克隆抗体所阻断。纳洛酮、μ阿片受体特异性拮抗剂β－ＦＮＡ能够阻断ＩＦＮα的镇痛作用，而δ和κ阿片受体特异性拮抗剂则没有这一作用，表明ＩＦＮα的中枢镇痛作用由μ阿片受体所介导。
With using the tail flick induced by electro stimulation as pain marker,it was found that pain threshold was increased significantly after injecting interferon α (IFNα) into the lateral cerebral ventricle of rats.This effect was dose dependent and abolished by monoclonal antibody to IFNα.Naloxone and specific antagonist of μ(not δ and κ)opiate receptor could inhibit the analgesic effect of IFNα,suggesting that the analgesic effect of IFNα be mediated by μ opiate receptor.
基金
上海市教委资助
上海市教育发展基金会曙光计划
关键词
Α干扰素
痛阈
阿片受体
侧脑室
镇痛
interferon α pain threshold opiate receptors lateral ventricle β FNA
