摘要
目的探讨一氧化氮（ＮＯ）在胃癌发病过程中的作用。方法４２例经胃镜活检、病理检查证实为胃癌，采用地高辛标记的诱导型一氧化氮合酶（ｉＮＯＳ）ｍＲＮＡ探针经原位杂交显示细胞内的ｉＮＯＳｍＲＮＡ的表达情况，并与癌周组织及浅表胃炎组织比较。结果在４２例胃癌患者，ｉＮＯＳｍＲＮＡ信号强阳性（＋＋＋）１１例，中度阳性（＋＋）１４例，低度阳性（＋）１３例，可疑阳性（±）３例，阴性（－）１例；在癌周组织多为（±）或（－）；与浅表性胃炎相比，差异有高度显著性（Ｐ＜０．０１）。结论大多数胃癌患者的癌细胞内ｉＮＯＳｍＲＮＡ表达阳性。
Objective To explore the effects of nitric oxide on the progression of gastric carcinoma (GC). Methods The expression of inducible nitric oxide synthase (iNOS) mRNA was detected by in situ hybridization in 42 GC tissues. Results Of the 42 GC tissues, 11 were strong positive signal (+++), 14 medium positive signal (++), 13 mild positived signal (+), 3 suspicious positive signal (±), 1 negative (-). The signal in pericancer tissus was almost (±) or (-). The positive expression rates of iNOS mRNA in GC tissue were significantly higher than that in superficial gastritis tissue ( P <0.01). Conclusions Most of the GC cells can express iNOS, which implies that GC cells may produce the nitric oxide. The nitric oxide may take part in the pathologic development of GC.
出处
《中国普通外科杂志》
CAS
CSCD
1999年第4期288-290,共3页
China Journal of General Surgery
关键词
胃肿瘤
病因学
腺癌
一氧化氮
STOMACH NEOPLASMS/ET ADENOCARCINOMA/ET NITRIC OXIDE
