摘要
目的分析前列地尔治疗急性百草枯中毒(PQ)肺损伤的疗效。方法将30例百草枯中毒患者随机分组分为治疗组15例和对照组15例,所有患者均接受序贯性血液净化(血浆置换+血液灌流+血液透析)联合综合治疗。对照组静脉注射甲泼尼龙;治疗组在对照组治疗基础上加用前列地尔。结果对照组40%患者有效,治疗组75%患者有效,两组间有效比例差异有统计学意义(P<0.05)。治疗组治疗后PaO2、PaCO2、PaO2/FiO2改善较对照组显著(P<0.05)。治疗组治疗后X线胸片提示肺损伤好转9例,显著多于对照组5例(P<0.05);死亡率两组无差异。结论前列地尔注射液可以显著改善动脉血气、呼吸参数,对急性PQ中毒肺损伤有积极的治疗作用。
Objective To analyze the efficacy ofalprostadil for treatment of pulmonary damage in acute paraquat poisoning. Methods 30 patients with paraquat poisoning were randomly divided into treatment group （n=15） and control group （n=15）, all patients underwent sequential blood purification （plasma exchange ＋ hemoperfusion ＋ hemodialysis） combined with comprehensive treatment. The control group was intravenously infused methylprednisolone; the treatment group was treated based on the use of alprostadil. Results In the control group 40% patients were effective, in the treatment group 75% patients were effective, the effective ratio between the two groups was signif- icant （P 〈0.05）. After treatment, PaO2, PaCO2, PaOJFiO2 improved significantly than the control group （P 〈0.05）. After treatment, X-ray prompted improvement in 9 patients with acute pulmonary damage, which were significantly more than the control group （n=5, P 〈0.05）; there was no difference in mortality. Conclusion Alprostadil injection can significantly improve arterial blood gas, respiratory parameters,which has a positive therapeutic effect on pulmonary damage in acute paraquat poisoning.
出处
《临床医学工程》
2011年第2期199-200,共2页
Clinical Medicine & Engineering
关键词
前列地尔
百草枯
急性中毒
肺损伤
Alprostadil
Pamquat
Acute poisoning
Pulmonary damage
