摘要
上皮-间质转化（EMT）使原发癌细胞获得间质特征,并且在转移部位上皮再生形成继发性肿瘤.该过程参与乳腺癌的浸润和转移,有可能影响疗效.乳腺癌细胞的一系列标记蛋白可监测转录调节和表观遗传调控引起的细胞学行为的特征性改变,并能够提供预测依据和治疗靶点.
Epithelial-mesenchymal transition cause primary carcinoma cells to acquire mesenchymal features and re-epithelialize to form a secondary mass at a metastatic site. Such plasticity has implications in the progression of breast carcinoma to metastasis, and will likely influence cancer＇s response to therapy. The transcriptional and epigenetic regulation that underlie the development of breast cancer and result in characteristic changes in cell behavior can be monitored using an array of marker proteins, providing the potential for emergent prognostic and therapeutic targeting.
出处
《国际肿瘤学杂志》
CAS
2011年第2期121-123,共3页
Journal of International Oncology
基金
基金项目：国家自然科学基金资助项目（81001186）
天津市自然科学基金资助项目（10JCYBJC14100）
关键词
乳腺肿瘤
肿瘤转移
预后
Breast neoplasms
Neoplasm metastasis
Prognosis
