摘要
紫杉醇类、长春碱类、铂类、沙利度胺及新药硼替佐米等常用化疗药物常可导致周围神经病变.预防或治疗化疗药物所致周围神经病变且不影响疗效的动物实验或临床试验相继进行,钙镁灌注、谷胱甘肽、硫辛酸等的应用研究也不断进展.
Chemotherapy- induced peripheral neuropathy （CIPN） can be caused by many commonly used chemotherapeutic agents, such as taxanes, vinca alkaloids, platinum drugs, thalidomide,and also by newer agents such as bortezomib. Both animal experiments and clinical studies are being conducted to investigate strategies for preventing CIPN or ameliorating established CIPN without affecting the antitumor efficacy of chemotherapy. Treatments using calcium and magnesium infusions,glutathione,lipoid acid are being evaluated for their clinical application.
出处
《国际肿瘤学杂志》
CAS
2011年第2期108-110,共3页
Journal of International Oncology
关键词
药物疗法
周围神经
药物毒性
化疗预防
Drag therapy
Peripheral nerves
Drug toxicity
Chemoprevention
