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CCL21／CCR7轴与肿瘤侵袭转移的机制

CCL21/CCR7 axis and mechanisms of tumor invasion and metastasis
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摘要 趋化因子CCL21具有双向效应,其通过与多种免疫细胞表面表达的受体CCR7结合,发挥抗肿瘤、抗感染等免疫效应,而多种肿瘤细胞表面亦表达CCR7,两者结合则促进肿瘤细胞的侵袭转移,导致肿瘤进展.故探析CCL21/CCR7与肿瘤侵袭转移机制,阻断其不利效应,使CCL21有希望用于肿瘤基因治疗. Secondary lymphoid tissue chemokine （CCL21） is a double-edged sword, which exerts antitumor, anti-infection immune response by binding to the receptor CCR7 on the surface of the multiple immune cells. However, a variety of tumor cells also express the receptor CCR7, the combination of CCL21 with CCR7promotes the invasion and metastasis of tumor cells, leading to the facilitation of tumor development. Therefore,exploring the mechanism（s） of tumor invasion and metastasis might be helpful for use of CCL21 as tumor gene therapy through blocking of CCL21＇s promotion of tumor invasion and metastasis.
作者 崔凯 张波 李胜
机构地区 山东省肿瘤医院肝胆外科
出处 《国际肿瘤学杂志》 CAS 2011年第2期96-99,共4页 Journal of International Oncology
关键词 趋化因子CCL21 受体 CCR7 肿瘤转移 淋巴转移 信号传导 Chemokine CCL21 Receptors, CCR7 Neoplasm metastasis Lymphatic metastasis Signal transduction
分类号 R730.2 [医药卫生—肿瘤]
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参考文献27

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国际肿瘤学杂志
2011年 第2期

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