摘要
[目的】观察丙泊酚中长链和长链脂肪乳剂对老年腹腔镜胆囊切除术（LC）患者肝功能和免疫功能的影响。【方法】行LC老年患者80例，ASAI～Ⅱ级，随机分为A、B两组，每组40人。A组采用1％长链脂肪乳注射液行麻醉诱导和维持。B组采用丙泊酚中／长链脂肪乳注射液行麻醉诱导和维持，常规监测心电图、血压、血氧饱和度。于术前、术后1h和术后24h测定肝功能及免疫功能的改变。【结果】B组术后24h肝功能血清丙氨酸转移酶、天门冬氨酸转移酶、总胆红素低于A组；与B组相比，A组IgG明显下降，差异均有显著性（P〈0．05）。【结论】丙泊酚中长链脂肪乳剂对老年LC患者肝功能和免疫的影响小，值得临床推广。
[Objective]To observe the effect of propofol medium- and long-chain fat emulsion on liver function and immune function in elderly patients undergoing laparoscopic cholecystectomy（I.C）. [Methods] Eighty ASA I --II elderly patients undergoing LC were randomly divided into group A and group B with 40 in each. Group A was induced and maintained anesthesia with 1 % propofol long-chain fat emulsion injection. Group B was induced and maintained anesthesia with propofol medium-chain fat emulsion injection. ECG, blood pressure and blood oxygen saturation were monitored. The liver function and immune function in patients before and lh, 24h after surgery were measured. [Results] At 24h after surgery, serum alanine aminotransfarase （ALT）, aspartate aminotransferase（AST） and total bilirubin（T Bili） in group A were higher than those in group A. Compared with group B, IgG in group A decreased obviously, and the difference was statistically significant（ P〈0.05）. [Conclusion]Propofol medium-chain fat emulsion has less effect on liver function and immune function in elderly patients undergoing I.C, so it is worthy of being extended.
出处
《医学临床研究》
CAS
2011年第1期76-78,共3页
Journal of Clinical Research
关键词
胆囊切除术
腹腔镜
酚类
cholecystectomy, laparoscoplc
phenols
