摘要
【目的】观察改良序贯疗法对幽门螺杆菌（Hp）的根除效果和安全性。【方法】既往未接受过根除治疗的Hp感染患者86例，随机分组接受10d舍左氧氟沙星的序贯治疗（序贯组）或10d传统三联治疗（对照纽）。疗程结束4周后，采用尿素呼气试验判断两组的Hp根除效果，同时比较其不良反应和依从性情况。【结果】最终有效病例79例，按ETT分析，序贯组根除率为83．7％，对照组为67．4％，两纽相比较差异无显著性；按PP分析，序贯组根除率为92．3％，对照组为72．5％，两组间差异有显著性（P〈0．05）。【结论】含左氧氟沙星的序贯疗法可以获得较好的根除率，该方案患者依从性好，不良反应发生率低，有望作为一有效的初治方案。
[Objective]To observe the efficacy and safety of modified sequential therapy for eradicating Helico bacter pylori（HP） infection. [Methods] Eighty-six patients with HP infection who did not receive eradicating therapy were randomly divided into two groups. Patients in sequential therapy group received 10-day sequential therapy with levofloxacin. Patients in conlrol group received triple therapy for 10 days. The effect of HP eradica tion was assessed by ^13C-urea breath test at 4 weeks after treatment. Meanwhile the side effect and compliance were recorded. [Results]Finally, there were 79 cases with good results. According to intention to-treat（ITT） a nalysis, the eradication rate of HP in the sequential therapy group and the traditional triple group were 83.7% and 67.4%, respectively, and there was no significant difference between two groups. According to per-protocol（PP） analysis, the eradieation rate of HP in the sequential therapy group and the traditional triple therapy group were 92. 3% and 72. 5%, respectively, and there was significant difference between two groups（ P 〈0. 05）. [Conclusion]Sequential therapy with levofloxacin has higher eradication rate, good compliance and lower incidence of the side reaction, so it is hopeful to be as an effective initial treatment regimen for HP eradication.
出处
《医学临床研究》
CAS
2011年第1期66-68,共3页
Journal of Clinical Research
