摘要
为了探讨内皮素（ＥＴ）在肺心病发病中的作用及卡托普利的治疗作用机理，将３６例肺心病患者随机分为两组，２０例采用常规治疗，１６例采用卡托普利加常规治疗，疗程为１４天，并以２０例健康人作为对照。用放射免疫分析法测定治疗前后血浆ＥＴ－１水平，并与患者动脉血氧分压（ＰａＯ２）进行相关分析。结果发现，肺心病患者治疗前ＥＴ－１水平明显高于对照组（Ｐ＜０．０１），与ＰａＯ２水平呈负相关（Ｐ＜０．０１），与ＰａＣＯ２、ｐＨ无明显相关（Ｐ＞０．０５）；治疗后两组患者血浆ＥＴ－１水平明显下降（Ｐ＜０．０１），但仍明显高于对照组（Ｐ＜０．０５），卡托普利组治疗后血浆ＥＴ－１水平显著低于常规治疗组（Ｐ＜０．０５）。提示内皮素在肺心病发病中起了重要作用，卡托普利的治疗作用与其降低ＥＴ水平有一定关系。
The purpose of this study was to investigate the role of endothelin(ET) in the development of cor pulmonale and the mechanism of captopril in treatment. The plasma ET1 levels of 36 patients with cor pulmonale and 20 normal subjects were measured by radioimmunoassay. Twenty patients were treated with antibiotics and oxygen, and the other 16 patients were treated with antibiotics, oxygen and captopril for 14 days. The results showed that the ET1 level of patients with cor pulmonale (88.98.9ng/L) was significantly higher than that of normal control (53.55.1ng/L). After treatment, the ET1 level declined significantly in both groups of patients (P<0.01); the ET1 level in patients treated with captopril was lower than that in patients not treated with captopril (P<0.05), but the level of ET1 in patients was still higher than that of normal control (P<0.05). These suggest that ET1 may play an important role in the onset of cor pulmonale and captopril can reduce the ET1 level.
出处
《华西医科大学学报》
CSCD
1999年第2期179-181,共3页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
