摘要
为探讨微血管在正常宫颈组织和宫颈鳞癌中的状况，采用免疫组化ＬＳＡＢ法对８０例宫颈鳞癌和１５例正常宫颈组织中的微血管数进行了检测。结果显示：①正常宫颈组织中微血管数明显低于宫颈鳞癌；②微血管数与宫颈鳞癌临床分期呈正相关（在２００倍显微镜视野下：Ⅰｂ期为１４．５１±６．５１根，Ⅱ期为１９．８４±４．７３根，Ⅲ期为３２．２６±６．８２根），与外生型肿瘤的菜花直径大小有关（在２００倍显微镜视野下：直径≤４ｃｍ，ＭＶＣ＝１８．０８±７．５６根；直径＞４ｃｍ，ＭＶＣ＝２３．９１±８．０５根），与淋巴结转移状况有关（ＬＰＧ＋，ＭＶＣ＝２４．１３±９．８３根；ＬＰＧ－，ＭＶＣ＝１８．５４±５．９９根），均Ｐ＜０．０５，且在２００倍显微镜下每增加５根血管，肿瘤发生淋巴结转移的机会将增加１．６１倍，而与组织学分级无关。结果提示：微血管计数能够反映宫颈癌的恶性潜能，是观察宫颈癌预后的重要指标。
This study was conducted to determine microvessel count(MVC) status in normal cervical tissue (NCT) and in cervical carcinomas(CCs). 15 cases of NCT and 80 cases of CCs were stained by immunohistochemical method for Factor related antigen (F8RA). The results showed that the MVC in CCs was much higher than that in NCT and it was correlated with clinical stage, size of tumor and lymph node status (P<0.05). Every time when MVC increased by 5 in number (LM200, field 0.739 mm2), the chance of lymph node metastasis increased by 1.61 times. There was no relationship between MVC and tumor grade. These suggested that MVC might be a useful early parameter in the diagnosis and prognosis of CCs.
出处
《华西医科大学学报》
CSCD
1999年第2期176-178,183,共4页
Journal of West China University of Medical Sciences
