摘要
目的 探讨重症监护病房（ICU）铜绿假单胞菌医院感染的危险因素,为制定医院感染的防治策略、措施提供依据.方法 采用回顾性病例对照研究和非条件Logistic多元回归分析方法,分析2002年1月至2006年12月1 950例ICU患者铜绿假单胞菌医院感染危险因素.结果 64例患者发生铜绿假单胞菌医院感染（作为感染组）,发生率为3.3%.同期与感染组同一科室的37例发生大肠埃希菌医院感染患者作为对照组.单因素分析结果：使用激素、昏迷或颅脑损伤、腹部手术、有胸腹引流管、机械通气、开放气道是铜绿假单胞菌医院感染的危险因素[使用激素：相对比值比（OR）=3.364,95%可信区间（95%CI）1.445～7.830;昏迷或颅脑损伤：OR=4.026,95%CI 1.545～10.490;腹部手术,OR=0.166,95%CI 0.068～0.403;有胸腹引流管：OR=0.350,95%CI 0.150～0.818;开放气道：OR=4.095,95%CI 1.638～10.740].多因素Logistic分析结果：铜绿假单胞菌医院感染的独立危险因素有使用激素、机械通气（使用激素：OR=3.143,95%CI 1.115～8.856;机械通气：OR=3.195,95%CI 1.607～6.353,P＜0.05和P＜0.01）.结论 使用激素和机械通气是铜绿假单胞菌医院感染的独立危险因素,应针对危险因素采取措施以控制医院感染.
Objective To investigate the risk factors of nosocomial infection caused by Pseudomonas aeruginosa in intensive care unit （ICU）, in order to provide reference for an effective measure of infection control. Methods A retrospective study of cases of Pseudomonas aeruginosa infection occurring in ICU was made with multivariable Logistic regression analysis. The clinical data of 1 950 cases admitted from January 2002 to December 2006 were found to have nosocomial infection caused by Pseudomonas aeruginosa were analyzed in order to identify its independent risk factors. Results Sixty-four out of 1 950 patients were found to suffer from nosocomial infection caused by Pseudomonas aeruginosa, the morbidity rate was 3.3%. At the same time, and in the same department, 37 patients suffering from infection caused by Escherichia coli, served as control group. Univariate analysis showed that the risk factors for nosocomial infection caused by Pseudomonas aeruginosa were the use of corticosteroid, unconsciousness or craniocerebral trauma, abdominal surgery, thorax/abdomen drainage tube, mechanical ventilation, and tracheostomy [the use of corticosteroid： odds ratio （OR）=3.364, 95% confidence interval （95%CI） 1.4457.830; unconsciousness or craniocerebral trauma： OR=4.026, 95%CI 1.54510.490; abdominal surgery： OR=0.166, 95%CI 0.0680.403; thorax/abdomen drainage tube： OR=0.350, 95%CI 0.1500.818;tracheostomy： OR=4.095, 95%CI 1.63810.740]. Multivariate analysis showed that the independent risk factors of nosocomial infection caused by Pseudomonas aeruginosa in ICU were： the use of corticosteroid and mechanical ventilation [the use of corticosteroid： OR=3.143, 95%CI 1.1158.856; mechanical ventilation： OR=3.195, 95%CI 1.6076.353, P〈0.05 and P〈0.01]. Conclusion The independent risk factors of nosocomial infection caused by Pseudomonas aeruginosa in ICU are the use of corticosteroid and mechanical ventilation. Measures should be taken to take care of the risk factors in order to prevent nosocomial infection caused by Pseudomonas aeruginosa in ICU.
出处
《中国危重病急救医学》
CAS
CSCD
北大核心
2011年第2期88-90,共3页
Chinese Critical Care Medicine
