摘要
目的观察奥曲肽和垂体后叶素序贯治疗食管静脉曲张破裂出血的疗效及副作用。方法５８例随机分为２组。治疗组２８例，奥曲肽首剂０１ｍｇ＋生理盐水２０ｍｌ静注，继之以奥曲肽２５μｇ·ｈ－１持续静滴，４８ｈ后改用垂体后叶素０１Ｕ·ｍｉｎ－１静滴至７２ｈ。对照组３０例，单用垂体后叶素。结果止血率：治疗组为８２１％（２３／２８），对照组为５６７％（１７／３０），两组差异有显著性（Ｐ＜００５）；平均输血量（ｍｌ）：治疗组为５２５±４２，对照组为６８０±６３，两组差异有显著性（Ｐ＜００５）；治疗组副作用亦明显减少且轻微。结论序贯疗法可提高疗效，减少副作用及输血量。
Objective Curative effect and side actions of octreotide and pituitrin were observed in the course of bleeding of esophageal varicose vein. Methods 58 cases were divided into 2 groups. In treatment group ( n =28) the initial dose of 0 1 mg octreotide was mixed in normal saline and transfused intravenously followed by the dose of 25 μg·h -1 for continuously intravenously dripping. Afrer 48 h 0 1 U/min pituitrin was given through iv dripping untill the therapy finished 72 h later. For control group ( n =30) only pituitrin was used. Results The effective rate for 2 groups was 82 1% and 56 7%, respectively ( P <0 05). The side effects in studied patients were much fewer and lighter than those of control. Furthermore, at the time blood volume transfused in average for each group also showed 525±42 ml in studied patients and 680±63 ml in the control( P <0 05). Conclusion The sequential treatment presents to be valuable with fewer side effects.
出处
《安徽医科大学学报》
CAS
1999年第2期127-128,共2页
Acta Universitatis Medicinalis Anhui
关键词
食管
静脉曲张
出血
奥曲肽
垂体后叶素
octreotide/ther use
pituitary hormones, posterior/ther use
esophageal and gastric varices/drug ther
gastrointestinal hemorrhage/drug ther
