摘要
目的：观察国产紫杉醇（紫素，ＴＡＸ）单药、与顺铂和５氟尿嘧啶联合治疗食管癌的疗效。方法：用从我国红豆杉中提取的ＴＡＸ治疗Ⅲ、Ⅳ期食管癌。单药治疗食管癌：ＴＡＸ１５０～１７５ｍｇ／ｍ２，静滴３小时，每３周一次，共２周期。ＴＡＸ／ＤＤＰ／５ＦＵ联合化疗：ＴＡＸ１３５ｍｇ／ｍ２，ｉｖ；ＤＤＰ每天２５ｍｇ／ｍ２，第１～３天静滴；５ＦＵ每天５００～７５０ｍｇ／ｍ２，第１～５天静滴。同期内用ＤＤＰ／５ＦＵ方案：ＤＤＰ每天２５ｍｇ／ｍ２，第１～３天静滴，５ＦＵ每天５００～７５０ｍｇ／ｍ２，第１～５天静滴。联合化疗每２８天重复为一周期，２～３周期为一疗程。结果：紫杉醇单药化疗有效率３３３％（３／９）；ＴＡＸ／ＤＤＰ／５ＦＵ治疗３０例食管癌的有效率为７７％（２３／３０）；ＤＤＰ／５ＦＵ治疗食管癌４５例，有效率为５３％（２４／４５）。前一联合方案的总有效率高于后者（Ｐ＜００５），不良反应也较后者重，但大多数患者能耐受。结论：紫杉醇是治疗食管癌的有效单药，与ＤＤＰ／５ＦＵ方案联用能明显提高疗效。
Objective: To study the effect and toxicity of Chinamade paclitaxel
in the treatment of esophageal cancer. Methods: In monotherapy,paclitaxel(TAX)was given to
patients with esophageal cancer in a does of 150175 mg/m2 per 3 weeks and one course
consisted of 2 cycles. In combination regiments,thirty patients received paclitaxel 135 mg/m2
by 3hour infusion on day1;cisplatin (DDP) 25 mg/m2 daily on days 1 through 3, and
5fluorouracil(5FU) at dose 500750 mg/m2 daily on days 1 through 5 At the same time,45
patients with esophageal cancer received cisplatin 25 mg/m2 daily on days 1 through 3, and
5fluorouracil at dose 500750mg/m2 daily days 1 through 5 Treatment was recycled evevry 28
days and one course consisted of 23 cycles. Results: Three of nine esophageal cancer patients
in monotherapy showed PR. The response rate of 30 esophageal cancer treated by
TAX/DDP/5FU was 77%(23/30),much higher than that of 45 patients treated by DDP/5FU (P<
005).The adverse effects of TAX/DDP/5FU were more common and more severe than DDP/5FU
group. Conclusion: Chinamade paclitaxel is effective in treating advanced esophageal
cancer.The effectiveness of DDP/5FU was enhanced significantly when paclitaxel was
combined.The toxic effects were tolerable to most of the patients.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第3期327-329,共3页
Chinese Journal of Cancer
基金
河南省重大项目基金
