摘要
目的：了解、评估术前介入治疗在骨肿瘤段截除手术中的选择与作用。方法：１９９２－１９９７年２６例骨肿瘤患者介入治疗后行瘤段切除重建术，观察临床、手术情况，按时随访。结果：１、术前介入治疗总有效率为９２％，膝、肩和髋部肿瘤的介入治疗均有良效。２、介入治疗使肿瘤坏死达到Ⅲ级以上，假包膜形成和肿瘤完整切除达到８８％。３、严重并发症是３例的皮肤坏死。４、随访显示：局部复发２例，转移２例，死亡５例，本组行保肢术的骨肉瘤患者的２年生存率为５３％。结论：术前介入治疗的效果明显，其作用在于：使肿瘤坏死缩小，分界变清，减少肿瘤血供，有利于完整切除肿瘤，减少局部复发、提高手术成功率。主要适用于：（１）恶性骨肿瘤拟行保肢治疗者。（２）良性或中间性骨肿瘤破坏范围大已难以保留患骨、估计肿瘤血供丰富者。
Objectives: To study and evaluate the value and selection of chemoembolization
before segmental resection of bone tumors. Methods: Twentysix bone tumors with segmental
resection after chemoembolization were based on the clinical manifestations and operations.All
cases were followed up. Results: (1)Good results were obtained in 92%cases by
preoperative chemoembolization,which were also good at knee,shoulder and hip region.(2)
Chemoembolization caused or degree necrosis in all cases.Formation of false membrane and
total removal of the tumors occurred in 88%cases.(3) Complication was skin necrosis occurring
in 3 cases.(4) Followed up:local reoccurrence was in 2 cases,metastasis in 2 cases,death from
metastasis in 5 cases.The 2year survival rate was 53%in cases with osteosarcoma in this
series. Conclusion: The results of preoperative chemoembolization showed to be effective.It
could make tumor necrosis and shrink,cause the edge clear, decrease blood supply to tumors
for benefic to remove the tumors thoroughly.The purposes were to decrease local recurrence
and improve successful rate of the operation.The indications for it were(1) the cases with
malignant tumor will be treated by limbsaving procedure;(2) benign or borderline tumors with
wide range destruction,which is difficult to remain the affected bone,and with rich blood supply.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第3期314-317,共4页
Chinese Journal of Cancer
基金
广东省科委科技重点攻关项目基金
关键词
骨肿瘤
截除术
化疗栓塞
手术前
Bone tumor
Embolization
Chemotherapy
Intervention treatment
Operation
