摘要
目的 探讨细胞内胞浆游离钙在老年性高血压患者心脏损害中的作用。方法 检测老年性高血压患者、中青年高血压患者及正常血压对照组细胞内胞浆游离钙浓度 ( [Ca2 +]i)、左心室重量指数 (LVMI)及左心室功能。结果 老年性高血压患者较中青年高血压患者和正常血压老年对照组LVMI和 [Ca2 +]i均显著升高 ,左心室舒张功能显著下降 ,收缩功能参数无显著改变。中青年高血压组较正常血压中青年对照组LVMI和[Ca2 +]i均显著升高 ,左心室舒张功能显著下降 ,收缩功能参数无显著改变。原发性高血压患者LVMI和[Ca2 +]i呈正相关 (r=0 7188,P <0 0 1)。结论 老年性高血压患者较中青年高血压患者存在更为严重的钙代谢紊乱及心脏损害 ,其心脏损害可能与他们存在更严重的钙代谢紊乱有关 。
Objective To examine the effect of intracellular free calcium([Ca 2+ ]i) in the pathogenesis of heart damage in elderly patients with essential hypertension. Methods [Ca 2+ ]i,left ventricular moss index (LVMI) and left ventricular function were determined in elderly hypertensive patients, middle-aged hypertensive patients and normotensive controls. Results To compare with middle-aged hypertensive patients and normotensive controls, [Ca 2+ ]i and LVMI were markly increased, left ventricular diastolic function were markly decreased (LVMI) and left ventricular systolic function revealed no changes in elderly hypertensive patients. There were positive correlation between the LVMI and [Ca 2+ ]i in essential hypertensive patients ( r =0 718 8, P <0 01). Conclusion The data confirmed that the confusion of intracellular calcium metabolism is more serious in elderly hypertensive patients than that in middle-aged hypertensive patients . The heart damage might link to the confusion of intracellular calcium metabolism.
出处
《广东医学》
CAS
CSCD
1999年第6期409-410,共2页
Guangdong Medical Journal
关键词
高血压
细胞内胞浆
游离钙
老年人
心脏损害
Hypertension Intracellular free calcium concentration Left ventricular mass Left ventricular function
