摘要
白血病干细胞(LSCs)是存在于白血病患者体内极少数具有自我更新和增殖能力的细胞,是白血病复发的根源。其具有自身独特的生物学性质,如某些特殊的细胞表面标志,及其自身的细胞周期特点。近年来,许多学者对LSCs的靶向治疗策略进行了探索,为彻底清除LSCs、达到临床长期稳定缓解提供了新的方向。蛋白质组是指细胞或组织基因组所表达的全部蛋白质。近年来,蛋白质组技术发展迅速,激光捕获微切割、蛋白质芯片等新技术促进了蛋白质组学的发展。运用蛋白质组学分析技术阐明蛋白质表达水平的变化与白血病发生发展的一些相互关系及规律,可以为进一步寻找新药和预后判断提供理论依据。现将蛋白质组学在LSCs中的研究进展综述如下。
Leukemic stem cells（LSCs） are the very few cells existed in leukemia patients which can update by themselves and prolife-rate,they are the root of leukemia relapsing.They have some unique biological properties,such as some specific phenotypes and unique cell cycle.During last few years,many researchers had explored the strategies for targeted therapy on the basis of phenotypic characteristics,for creating new trends in leukemia treatment,which might be essential to achieve stable,long-lasting remission.Proteomics consists of all the proteins expressed in the cells and organizations.With the rapid development of latest techniques such as laser capture microdissect,surface-enhanced laser desorption/ionization time-of-flight,the progress of research in proteomics has been promoted.It illuminates the correlation of protein′s expression with the occurrence and development of leukemia,so as to provide the scientific evidences for searching new drugs and diagnosing prognosis.The advanced researches on proteomics in LSCs are briefly stated.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第3期208-211,共4页
Journal of Applied Clinical Pediatrics
基金
四川省科技支撑项目(2008SG0035)
