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造血干细胞移植治疗原发性免疫缺陷病 被引量：9

Hematopoietic Stem Cell Transplantation for Primary Immunodeficiency Disease
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摘要 原发性免疫缺陷病(PID)是一组少见的遗传性疾病,患儿往往发生反复感染,因而生命受到严重威胁。造血干细胞移植是唯一能够治愈该病的方法。目前认为人类白细胞抗原(HLA)相合的同胞是最佳的造血干细胞供者。但随着造血干细胞移植技术的发展,非亲缘HLA相合、单倍体相合供者亦成为PID患者可供选择的造血干细胞来源。由于脐带血干细胞库的建立,脐带血干细胞移植成功治疗PID的例数也日益增加。现就不同供者及移植物来源的造血干细胞在严重联合免疫缺陷病、Wiskott-Aldrich综合征、高IgM综合征以及慢性肉芽肿病的移植治疗的特点及进展进行综述。
作者 于洁 王玥 陈飞
机构地区 重庆医科大学附属儿童医院血液/肿瘤科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2011年第3期157-162,共6页 Journal of Applied Clinical Pediatrics
关键词 造血干细胞移植 原发性免疫缺陷病 严重联合免疫缺陷病
分类号 R725.9 [医药卫生—儿科]
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参考文献44

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同被引文献72

  • 1汤宇,谢佳芯,许家军.羊膜上皮细胞的干细胞样特性[J].解剖科学进展,2010,16(5):478-482. 被引量：4
  • 2Chun-Juan Guo , Ying Gao , Di Hou , Dong-Yan Shi , Xiang-Min Tong , Dan Shen , Yong-Mei Xi , Jin-Fu Wang.Preclinical transplantation and safety of HS/PCs expanded from human umbilical cord blood[J].World Journal of Stem Cells,2011,3(5):43-52. 被引量：4
  • 3陈同辛,王玺.原发性免疫缺陷病诊断标准[J].实用儿科临床杂志,2006,21(9):573-576. 被引量：38
  • 4顾东生,刘斌,韩忠朝.脐带血干细胞的基础与应用研究[J].生命科学,2006,18(4):323-327. 被引量：17
  • 5刘颖中,钟雁,王亚娟.湿疹-血小板减少紫癜综合征1例报告及文献复习[J].中国当代儿科杂志,2006,8(6):499-501. 被引量：5
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  • 10Ozsahin H, Cavazzana-Calvo M, Notarangelo LD, et al. Long- term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the Europe- an Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation [J]. Blood, 2008, 111 ( 1 ): 439-445.

引证文献9

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实用儿科临床杂志
2011年 第3期

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