摘要
IgA肾病(IgAN)是全球最为常见的肾小球肾炎,也是终末期肾衰竭的重要原因。近年来在其致病机制、病理分型、预后因素及治疗方面取得了许多振奋人心的成果。糖基化异常IgA1的发现不但有助于了解其分子致病机制,而且可能成为IgAN早期无创性诊断的分子标志物;全基因组关联研究已被证实对复杂性疾病的中效或微效致病基因定位效能要优于传统连锁分析方法,该技术应用于IgAN致病基因定位研究已取得很有希望的结果,而下一代测序技术的不断完善将推动进一步的基因定位;Oxford病理分型是迄今最为科学的IgAN病理分型系统,尽管该分型方法推广前还需进一步验证。这些研究成果必将加深我们对该病的认识,本文将就这些进展进行论述。
Summary：IgA nephropathy （IgAN） is the most prevalent glomerulonephritis and is also the important cause of end stage renal disease. Results have been made on the mechanism, pathology classification, prognosis factors and treatment of IgAN in the recent years. The discovely of Gd-IgA1 will help to understand the molecular mecha- nism for IgAN and it may become an early non-invasive bio-marker of IgAN diagnosis. Genome wide association study （GWAS） has been confirmed to have the greater advantage for moderate or minor effect gene localization in complex disease compared to conventional linkage method. GWAS in localizing in IgAN causal gene has achieved striking results. Furthermore,the improvement of ＂Next-Gen Sequencing ＂ technique will further help gene localization. Oxford pathology classification has been regarded as the most scientific pathological scoring system of IgAN to date,although still needs further confinmation. All these achievements lead tofurther understanding of the disease.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2011年第2期90-93,共4页
Chinese Journal of Practical Internal Medicine
