阿托伐他汀联合阿魏酸钠治疗慢性肾小球肾炎被引量：9

Treatment of combined atorvastatin and sodium ferulate on chronic glomerulonephritis

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摘要目的观察阿托伐他汀联合阿魏酸钠治疗慢性肾小球肾炎的疗效。方法将56例慢性肾小球肾炎患者随机分为治疗组(30例),应用阿托伐他汀联合阿魏酸钠治疗,对照组(26例)应用辛伐他汀,疗程2个月,检查尿蛋白(U-pro)、血尿素氮(BUN)、肌酐(Cr)、肾小球滤过率(GFR)指标的变化情况。结果经过2个月治疗,两组间Cr、BUN、GFR、U-pro水平有差异(P<0.05)。而治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)在两组间无差异(P>0.05)。结论阿托伐他汀联合阿魏酸钠可延缓血管内皮损,对肾功能有一定保护作用。 Objective To investigate the effect of atorvastatin and sodium ferulate on chronic glomerulonephritis.Methods 56 patients with chronic glomerulonephritis were divided randomly into 2 groups,including treatment group（30 patients） treated with atorvastatin and sodium ferulate and control group（26 patients） treated with simvastatin.Urine protein（U-pro）,serum creatinie（Cr）,blood urea nitrogen（BUN） and glomerular filtration rate（GFR） were detected.Results U-pro,Cr,BUN of treatment group showed a significant difference from that on control group（P0.05）.Total cholesterol（TC）,triglyceride（TG）, low density lipoprotein cholesterol（LDL-C）,high density lipoprotein cholesterol（HDL-C） of showed treatment group no significant difference from that of control group（P0.05）.Conclusion Atorvastatin and sodium ferulate can delay the development of renal lesions and protect renal function.

作者肖迎春钱晓惠

机构地区泰州市人民医院肾内科

出处《西部医学》 2011年第2期250-252,共3页 Medical Journal of West China

关键词阿托伐他汀阿魏酸钠慢性肾小球肾炎 Atorvastatin Sodium ferulates Chronic glomerulonephritis

分类号 R692.31 [医药卫生—泌尿科学]

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1Usui H, Shikata K, Matsuda M, etal. HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats [J]. Nephrol Dial Transplant, 2003, 18(2) :265-272.
2陈灏珠,主编.实用内科学[M]第12版.北京:人民卫生出版社,2005.1 231-1 245.
3成田一衛,史春虹.慢性肾小球肾炎[J].日本医学介绍,2007,28(7):289-291. 被引量：9
4Tesar V. Some important news in ellnieal nephrology in yesrs 2003-2004[J].Vnitr Lek, 2004, 50 (Suppl 1):81-87.
5高璐,于德民.他汀类药物在肾脏疾病防治中的研究进展[J].国外医学（泌尿系统分册）,2004,24(1):91-93. 被引量：11
6孙田美,梅长林,葛守一,徐成钢,赵海丹,李林,张树忠,盛茂.洛伐他汀对系膜细胞凋亡及Bcl-2和Bax基因表达的影响[J].中华肾脏病杂志,2003,19(1):38-42. 被引量：21
7Sidaway J, Davidson R, McTaggart F, et al. Inhibitors of 3- Hydroxy-3- Methylgutaryl-CoA reduetase reduce receptor- mediated endocytosis in opossum kidney ceils [J]. J Am Soc Nephrol, 2004, 15(9) :2258-2265.
8Verhulst A, D'Haese P, De Broe Me. Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells [J]. J Am Soc Nephrol, 2004, 15(9): 2249-2257.
9Athyros VG, Miekhailidis DP, Papageorgiou AA, et al. The effect of statins versus untreated dyslipidaemia on renal function in patients with coronary heart disease. A subgroup analysis of the Greek atorvastain and coronary heart disease evaluation (GREACE)study [J]. J Clin Pathol, 2004, 57(7):728-734.
10Economides PA, Caselli A, Tiani E, etal. The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2 diabets[J]. J Clin Endocrinol Metab, 2004, 89 (2) :740-747.

二级参考文献48

1李学旺,李航.炎症是脂质异常介导的动脉粥样硬化和肾脏损害的中心环节[J].中华肾脏病杂志,2005,21(9):499-501. 被引量：34
2成田一衛,史春虹.慢性肾小球肾炎[J].日本医学介绍,2007,28(7):289-291. 被引量：9
3于宁赵秀珍等.原发性肾病综合征病人血浆D－二聚体的检测[J].青岛大学医学院学报,2000,35(2):130-130.
4Usui H,Shikata K Matsuda M,et al.HMG-CoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats[J].Nephrol Dial Transplant,2003,18(2):265-272.
5Tesar V.Some important news in clinical nephrology in yesrs2003-2004[J].Vnitr Lck,2004,50(Suppl1):81-87.
6Eennomides PA,Caselli A,Tiani E,et al.The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2,diabcts[J].J Clin Endocrinol Metab,2004,89(2):740-747.
7Yokota N,O'Doonell M,Daniels F,et al.Protective effect of HMG-CoA reductase inhibitor on experimental renal isehemiareperfusion injury[J].Am J Nephrol,2003,23(1):13-17.
8Nakamura T,Ushiyama C,Hirokawa K,et al.Effect ofeerivastatin on proteinuria and urinary podocvtes in patients、with chronic glomerulonephritis[J].Ncphrol Dial Transplant,2002,17(5):798-802.
9Sidaway J,Davidson R,McTaggart F,et al.Inhibitom of 3-Hydroxy-3-Mcthylgutaryl-CoA reductase reduce receptor-meadiated endoeytosis in opossum kidney ceils[J].J Am Soc Nephrol,2004,15(9):2258-2265.
10Verhuist A,D'Haese P,De Broe Me.Inhibitors of HMG-CoAreductase reduce receptor-mediated endocytosis in human kidney proximal tubular ceils[J].J Am Soc Nephrol,2004,15(9):2249-2257.