摘要
目的观察黄连素联合氟哌噻吨美利曲辛片治疗腹泻型肠易激综合征(IBS)的临床疗效。方法将120例肠易激综合征患者随机分为2组,对照组60例给予黄连素300 mg,每日3次口服;观察组60例给予黄连素300 mg,每日3次口服,加用氟哌噻吨美利曲辛片1片,每日2次口服。2组疗程均为12周,观察临床疗效及不良反应。结果观察组总有效率95%,对照组总有效率75%,2组总有效率比较差异有统计学意义(P<0.05)。2组药物耐受性及安全性良好,整个疗程未见明显不良反应。结论黄连素联合氟哌噻吨美利曲辛片治疗腹泻型肠易激综合征疗效较好,无明显不良反应。
Objective To observe the therapeutic effect of diarrhea-predominant irritable bowel syndrome treated by combination of Berberine and Flupentixol and Melitracen tablets.Methods 120 patients with diarrhea-predominant irritable bowel syndrome were randomly divided into two groups.60 cases in control group were treated by Berberine（300 mg,thrice a day）.60 patients in treatment group were treated by combination of Berberine（300 mg,thrice a day） and Flupentixol and Melitracen tablets（a pills,twice a day）.The effect and side effect were observed after a course（12 weeks）.Results The total effective rate in treatment group（95.0%） was higher than that in control group（75.0%,P〈0.05）.The tolerance and safety of medicine in two groups was good.There was no obvious side effect.Conclusion The effect of combination of Berberine and Flupentixol and Melitracen tablets was definite on diarrhea-predominant irritable bowel syndrome.
出处
《河北中医》
2010年第12期1826-1827,共2页
Hebei Journal of Traditional Chinese Medicine
基金
河北省科学技术研究与发展计划项目(编号:05276456)
关键词
肠易激综合征
腹泻
小檗碱
氟哌噻吨美利曲辛
Irritable bowel syndrome
Diarrhea
Berberine hydrochloride
Flupentixol and Melitracen tablets
