摘要
从苯乙酸、乙酐开始分四步合成了利法二酮(LiphapioneⅥ).制备苯丙酮(Ⅰ)用非离子活性剂促进碱解其烯醇的乙酸酯较好,产率62.6%.在Ⅰ溴代时用乙酸作溶剂、过溴化物 DPBD 作催剂,产率91.4%.在Ⅵ的制备时以吡啶作溶剂、PEG-甲醇钠作催化剂,产率47.3%.后三步总产率为36.7%,高于文献值的21%.
We Synthesized the title Compound(Ⅵ)in 4 Steps,Starting from phenylacetic acid and acetic anphydride.In preparation of phenylacetone(1)nonionic active agent Was used as Catalyst of the hydrolysis of enol acetale,satisfactory result had been obtain -ed(in 62.6% yield).Supersbromide DpBD catalyzed bromination of I in acetic acid gave high yield(91.4%)1-bromo-1-phenylacet -one(Iv).Friedel-crafts alkylation of Chborobenzene by Iv gave 85% V.In preparation:of Ⅵ pyridine We used as Solvent and PE- G-Sodium Methoxide was used as Catalyst,which gave 47.3% V1. Thus the title compound was prepared in 3 steps starting from I in 36.7% yield,which was higher than 21% reported in the refereuce.
出处
《四川师范学院学报（自然科学版）》
1990年第4期321-324,共4页
Journal of Sichuan Teachers College(Natural Science)
关键词
利法二酮
合成
杀鼠药
抗凝血药
liphadione,2-(1-p-chlorophenyl-1-phenylacetvl-)-indane-1
3-dione
ratsbane
